世界科学技术-中医药现代化
世界科學技術-中醫藥現代化
세계과학기술-중의약현대화
WORLD SCIENCE AND TECHNOLOGY-MODERNIZATION OF TRADITIONAL CHINESE MEDICINE
2014年
12期
2652-2657
,共6页
附子%黑顺片%产地%急性心衰
附子%黑順片%產地%急性心衰
부자%흑순편%산지%급성심쇠
Aconite%black prepared lateral root of aconite%producing area%acute heart failure
目的：研究不同产地四川江油附子、四川凉山附子、云南禄劝附子、陕西汉中附子对急性心衰大鼠心功能指标的影响及其作用机制。方法：用戊巴比妥钠建立大鼠急性心衰模型，各组均以给药前各项指标对照，16道生理记录仪同步记录左室内压（LVSP），左室内压最大上升速率（+dp/dtmax），左室内压最大下降速率（-dp/dtmin），动态观察不同产地附子醇提物（5 g·kg-1）对急性心衰大鼠心功能指标及血浆中精氨酸加压素（AVP）、内皮素-1（ET-1）、心钠素（ANP）、血管紧张素（A域）水平变化及脑钠素（BNP）基因合成与表达的影响。结果：不同产地附子均能升高急性心衰大鼠左室内压，提高左心室+dp/dtmax和-dp/dtmin；并能降低心衰大鼠血浆中AVP水平含量、抑制心室肌内BNP基因的合成和表达，与抑制缩血管因子ET-1、A域水平及ANP基因表达无关。结论：不同产地附子炮制品均能改善大鼠心功能指标，其作用机制与左室功能抑制，心室肌收缩有关；对血管收缩导致的心脏后负荷增加有抑制作用，对前负荷增加无影响。并以道地产区江油附子作用最为明显，表明以功效为核心的中药质量评价模式来评价药材品质、控制药材质量的可行性。
目的：研究不同產地四川江油附子、四川涼山附子、雲南祿勸附子、陝西漢中附子對急性心衰大鼠心功能指標的影響及其作用機製。方法：用戊巴比妥鈉建立大鼠急性心衰模型，各組均以給藥前各項指標對照，16道生理記錄儀同步記錄左室內壓（LVSP），左室內壓最大上升速率（+dp/dtmax），左室內壓最大下降速率（-dp/dtmin），動態觀察不同產地附子醇提物（5 g·kg-1）對急性心衰大鼠心功能指標及血漿中精氨痠加壓素（AVP）、內皮素-1（ET-1）、心鈉素（ANP）、血管緊張素（A域）水平變化及腦鈉素（BNP）基因閤成與錶達的影響。結果：不同產地附子均能升高急性心衰大鼠左室內壓，提高左心室+dp/dtmax和-dp/dtmin；併能降低心衰大鼠血漿中AVP水平含量、抑製心室肌內BNP基因的閤成和錶達，與抑製縮血管因子ET-1、A域水平及ANP基因錶達無關。結論：不同產地附子砲製品均能改善大鼠心功能指標，其作用機製與左室功能抑製，心室肌收縮有關；對血管收縮導緻的心髒後負荷增加有抑製作用，對前負荷增加無影響。併以道地產區江油附子作用最為明顯，錶明以功效為覈心的中藥質量評價模式來評價藥材品質、控製藥材質量的可行性。
목적：연구불동산지사천강유부자、사천량산부자、운남록권부자、협서한중부자대급성심쇠대서심공능지표적영향급기작용궤제。방법：용무파비타납건립대서급성심쇠모형，각조균이급약전각항지표대조，16도생리기록의동보기록좌실내압（LVSP），좌실내압최대상승속솔（+dp/dtmax），좌실내압최대하강속솔（-dp/dtmin），동태관찰불동산지부자순제물（5 g·kg-1）대급성심쇠대서심공능지표급혈장중정안산가압소（AVP）、내피소-1（ET-1）、심납소（ANP）、혈관긴장소（A역）수평변화급뇌납소（BNP）기인합성여표체적영향。결과：불동산지부자균능승고급성심쇠대서좌실내압，제고좌심실+dp/dtmax화-dp/dtmin；병능강저심쇠대서혈장중AVP수평함량、억제심실기내BNP기인적합성화표체，여억제축혈관인자ET-1、A역수평급ANP기인표체무관。결론：불동산지부자포제품균능개선대서심공능지표，기작용궤제여좌실공능억제，심실기수축유관；대혈관수축도치적심장후부하증가유억제작용，대전부하증가무영향。병이도지산구강유부자작용최위명현，표명이공효위핵심적중약질량평개모식래평개약재품질、공제약재질량적가행성。
This article was aimed to study influence on heart function indexes and its mechanism of aconite from Jiangyou in Sichuan province, Liangshan in Sichuan province, Luquan in Y unnan province, and Hanzhong in Shanxi province among rats with acute heart failure (AHF). The AHF model rat was induced by injecting pentobarbital sodi-um. Parameters including the left ventricular pressure (LVSP), the maximum rate of pressure rise of left ventricular pressure (+dp/dtmax), the largest decline in the rate of left ventricular pressure (-dp/dtmin) were detected with 16 physi-ological recorder. The ethanol extractions of aconite (5 g·kg-1) with different origins were administered to AHF rats to observe the influence on heart function indexes and concentration changes of AVP, ET-1, ANP, AII, and the syn-thesis and expression of BNP gene. The results showed that aconite from different origins can increase the LVSP,+dp/dtmax, -dp/dtmin of AHF rats. It can also decrease the concentration of AVP, inhibit synthesis and expression of BNP gene. It was irrelevant to the inhibition of vasoconstrictor factor of ET-1, AII and ANP gene expression. It was concluded that processed aconite from different origins can improve the heart function indexes of rats. The mecha-nism was correlated to the inhibition of left ventricular and ventricular contraction. It had inhibiting effect on after-load, but no effect on preload. The effect of aconite from Jiangyou, which was the geo-authentic product area, was the most obvious one. It showed the feasibility of using effect as core Chinese medicine quality evaluation mode in the quality control of Chinese medicine.
