CAJ | 학술논문

目的：探讨骨膜蛋白（Periostin，POSTN）在三脑室底内型颅咽管瘤中表达及意义。方法回顾性分析42例手术病理证实的成釉细胞型且外科分型为三脑室底内型的颅咽管瘤患者资料，对其病理切片进行POSTN免疫组化染色，分析染色程度和肿瘤与三脑室底粘连程度、术后下丘脑功能和复发情况的关系。结果POSTN表达于颅咽管瘤间质成分，表达程度和术后复发率无统计学意义（Z=-0.236，P=0.813），但和肿瘤与三脑室底粘连程度（r=0.685，P<0.001）、术后下丘脑评分（r=0.569，P<0.001）及术后随访期BMI（r=0.594，P<0.001）有相关性。结论 POSTN反映三脑室底内型颅咽管瘤和下丘脑粘连程度，其高表达预测着更差的下丘脑功能状态。
목적：탐토골막단백（Periostin，POSTN）재삼뇌실저내형로인관류중표체급의의。방법회고성분석42례수술병리증실적성유세포형차외과분형위삼뇌실저내형적로인관류환자자료，대기병리절편진행POSTN면역조화염색，분석염색정도화종류여삼뇌실저점련정도、술후하구뇌공능화복발정황적관계。결과POSTN표체우로인관류간질성분，표체정도화술후복발솔무통계학의의（Z=-0.236，P=0.813），단화종류여삼뇌실저점련정도（r=0.685，P<0.001）、술후하구뇌평분（r=0.569，P<0.001）급술후수방기BMI（r=0.594，P<0.001）유상관성。결론 POSTN반영삼뇌실저내형로인관류화하구뇌점련정도，기고표체예측착경차적하구뇌공능상태。
Objective To evaluate the expression and clinical significance of Periostin (POSTN) in craniopharyngi?oma. Methods Forty-two patients with pathologically diagnosed adamantinomatous craniopharyngioma involving the floor of 3rd ventricle were retrospectively analyzed. The correlation between expression of POSTN and outcome was studied. Results POSTN was expressed in stroma of craniopharyngioma tissues. The expression of POSTN was not associated with the postoperative recurrence (Z=-0.236,P=0.813) while was associated with the degree of the adhesion between tumor and floor of 3rd ventricle (r=0.685, P<0.001), postoperative Hypothalamic Status Scale (r=0.569, P<0.001) and Body Mass Index (r=0.594, P<0.001). Conclusions POSTN may predict the degree of the adhesion between craniopharyngioma and 3rd ventricle floor. The high expression of POSTN may indicate the worse hypothalamus function.