CAJ | 학술논문

目的探讨单胺氧化酶A（monoamine oxidase A, MAOA）rs1137070基因多态性与儿童期躯体受虐因素的交互作用对酒精依赖患者家庭暴力行为的影响。方法对284例新疆地区酒精依赖患者进行问卷调查，通过家庭暴力问卷调查表获得社会人口学资料、施暴（有或无）及施暴的表现形式，采用修改版外显行为攻击量表和修订版Barratt冲动量表对攻击行为进行评估并分组，采用儿童受虐筛查表与儿童受虐量表联合调查儿童期躯体受虐情况。直接测序法检测患者MAOA基因rs1137070位点的多态性。根据叉生分析相加模型交互作用指标判断基因与儿童期躯体受虐因素的交互作用。结果施暴组和对照组分别为146例和138例患者。儿童期受虐与rs1137070位点等位基因是新疆汉族及维吾尔族酒精依赖患者家庭暴力行为的危险因素。儿童期受虐与rs1137070等位基因存在相加模型正交互作用，两者的超额相对危险度、交互作用归因比、交互作用指数分别为1.00、0.14和1.20。结论新疆汉族及维吾尔族酒精依赖患者家庭暴力行为的发生是儿童期受虐因素及遗传危险因素共同作用的结果，儿童期受虐因素与rs1137070等位基因共同影响家庭暴力行为的发生。
목적탐토단알양화매A（monoamine oxidase A, MAOA）rs1137070기인다태성여인동기구체수학인소적교호작용대주정의뢰환자가정폭역행위적영향。방법대284례신강지구주정의뢰환자진행문권조사，통과가정폭력문권조사표획득사회인구학자료、시폭（유혹무）급시폭적표현형식，채용수개판외현행위공격량표화수정판Barratt충동량표대공격행위진행평고병분조，채용인동수학사사표여인동수학량표연합조사인동기구체수학정황。직접측서법검측환자MAOA기인rs1137070위점적다태성。근거차생분석상가모형교호작용지표판단기인여인동기구체수학인소적교호작용。결과시폭조화대조조분별위146례화138례환자。인동기수학여rs1137070위점등위기인시신강한족급유오이족주정의뢰환자가정폭역행위적위험인소。인동기수학여rs1137070등위기인존재상가모형정교호작용，량자적초액상대위험도、교호작용귀인비、교호작용지수분별위1.00、0.14화1.20。결론신강한족급유오이족주정의뢰환자가정폭역행위적발생시인동기수학인소급유전위험인소공동작용적결과，인동기수학인소여rs1137070등위기인공동영향가정폭역행위적발생。
Objective To investigate the effects of the interaction between environmental factors and monoamine oxidase A (MAOA) gene polymorphism in Han and Uygur on alcoholics in Xinjiang. Methods The data of childhood abuse and domestic aggressive behaviors were collected from 284 patients with alcohol dependence from Xinjiang using self-made questionnaires, Modified Overt Aggression Scale (MOAS) and Barratt Impulsivity Scale-11 (BIS-11). The meth?ods of PCR and DNA sequencing technique were conducted to detect rs1137070 single nucleotide polymorphism loci of MAOA gene. Logistic regression analysis was performed to adjust for interaction effects of gene and childhood abuse on domestic violence. Results The scale evaluation identified 143 patients with and 138 patients without domestic violence. Childhood abuse and gene were both risk factors in domestic violence. The interaction effect of childhood abuse with rs1137070 was significant. the relative excess risk, the interaction attribution ratio and the interaction index were 1.00,0.14 and 1.20, respectively. Conclusions The interactions between genes and environmental risk factors may contribute to the domestic violence in Han and Uygur on alcoholics in Xinjiang.