CAJ | 학술논문

目的：探讨心肌病相关基因5（cardiomyopathy associated 5，CMYA5）rs3828611位点基因多态性与新疆维吾尔族人群精神分裂症的关联性。方法通过Taq-man探针分型技术，对684例维吾尔族精神分裂症患者及678名维吾尔族正常对照的CMYA5基因rs3828611位点进行基因分型，采用阳性与阴性症状量表（pos?itive and negative symptoms scale，PANSS）评估患者症状。结果患者组与对照组间，rs3828611位点基因型与等位基因频率分布差异均无统计学意义（P>0.05）；患者组男性与对照组男性、患者组女性与对照组女性间rs3828611位点基因型与等位基因频率分布差异均无统计学意义（P>0.05）；青少年发病的患者与青少年对照之间，以及成年发病的患者与成年对照间等位基因和基因型频率差异无统计学意义（P>0.05）。不同基因型患者之间PANSS量表评分差异无统计学意义（P>0.05）。结论 CMYA5基因rs3828611位点多态性与新疆维吾尔族精神分裂症无明显关联。
목적：탐토심기병상관기인5（cardiomyopathy associated 5，CMYA5）rs3828611위점기인다태성여신강유오이족인군정신분렬증적관련성。방법통과Taq-man탐침분형기술，대684례유오이족정신분렬증환자급678명유오이족정상대조적CMYA5기인rs3828611위점진행기인분형，채용양성여음성증상량표（pos?itive and negative symptoms scale，PANSS）평고환자증상。결과환자조여대조조간，rs3828611위점기인형여등위기인빈솔분포차이균무통계학의의（P>0.05）；환자조남성여대조조남성、환자조녀성여대조조녀성간rs3828611위점기인형여등위기인빈솔분포차이균무통계학의의（P>0.05）；청소년발병적환자여청소년대조지간，이급성년발병적환자여성년대조간등위기인화기인형빈솔차이무통계학의의（P>0.05）。불동기인형환자지간PANSS량표평분차이무통계학의의（P>0.05）。결론 CMYA5기인rs3828611위점다태성여신강유오이족정신분렬증무명현관련。
Objective To investigate the association between Cardiomyopathy associated 5 (CMYA5) polymor?phisms and schizophrenia in the Uygur Chinese population. Methods Taq-man assay was used to detect CMYA5 gene rs3828611 in 684 schizophrenia patients and 678 healthy controls from Chinese population. The positive and negative symptoms scale (PANSS) was used to evaluate patients’symptoms. Results Neither the genotype nor the allele frequen?cies of rs3828611 was significantly different between the patients and the controls (P>0.05). The differences were not sig?nificant in either each gender subgroup or in each age (teenager and adult) subgroup (P>0.05). The total score and the sub scores of PANSS were not significantly different among patients with different genotype groups (P>0.05). Conclu?sions There is no association between CMYA5 rs3828611and schizophrenia in the Uygur Chinese population.