CAJ | 학술논문

目的：探讨首发重度抑郁症患者血清中促炎物质IL-1α、IL-6、IL-18、肿瘤坏死因子（ TNF-α）以及血清总补体活性（ CH50）水平的变化，以期对首发抑郁症的诊断有所帮助。方法采用汉密尔顿抑郁量表（HAMD）对首发抑郁症患者进行抑郁评分，采用酶联免疫吸附法（ELISA）检测49例首发重度抑郁症组患者和40例体检健康人正常对照组其血清中IL-1α、IL-6、IL-18、TNF-α及CH50的水平。结果首发重度抑郁症患者血清中IL-6、IL-18、TNF-α及CH50水平与正常对照组差异有统计学意义（P＜0．05），而IL-1α则无明显差异（P＞0．05）；在首发重度抑郁症男女性别分组中，血清中IL-1α水平差异有统计学意义（P＜0．05），IL-6、IL-18、TNF-α及CH50水平差异无统计学意义（P＞0．05）。结论细胞因子IL-6、IL-18、TNF-α及CH50可能参与或伴随首发重度抑郁症的发生和发展，可以作为首发重度抑郁症的辅助诊断指标。
목적：탐토수발중도억욱증환자혈청중촉염물질IL-1α、IL-6、IL-18、종류배사인자（ TNF-α）이급혈청총보체활성（ CH50）수평적변화，이기대수발억욱증적진단유소방조。방법채용한밀이돈억욱량표（HAMD）대수발억욱증환자진행억욱평분，채용매련면역흡부법（ELISA）검측49례수발중도억욱증조환자화40례체검건강인정상대조조기혈청중IL-1α、IL-6、IL-18、TNF-α급CH50적수평。결과수발중도억욱증환자혈청중IL-6、IL-18、TNF-α급CH50수평여정상대조조차이유통계학의의（P＜0．05），이IL-1α칙무명현차이（P＞0．05）；재수발중도억욱증남녀성별분조중，혈청중IL-1α수평차이유통계학의의（P＜0．05），IL-6、IL-18、TNF-α급CH50수평차이무통계학의의（P＞0．05）。결론세포인자IL-6、IL-18、TNF-α급CH50가능삼여혹반수수발중도억욱증적발생화발전，가이작위수발중도억욱증적보조진단지표。
Objective To provide supportive evidences for the diagnosis of primary major depres-sive disorder (MDD) by analyzing the alterations of proinflammatory cytokines such as IL-1α, IL-6, IL-18, TNF-αas well as the total complement activity (CH50) in serum samples.Methods Hamilton Depression Rating Scale ( HAMD) was used to rate the severity of depression with the patients who were diagnosed as primary MDD.Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of IL-1α, IL-6, IL-18 and TNF-αand the CH50 in serum samples from 49 patients and 40 healthy subjects .Results Pa-tients with MDD showed significantly different levels of IL-6, IL-18, TNF-αand CH50 in serum samples as compared with that in healthy subjects (P<0.05).No significant difference with the level of IL-1αwas ob-served between the patients with MDD and healthy subjects (P>0.05).There were significant gender differ-ences with levels of IL-1αamong the patients with MDD (P<0.05).However, no significant differences with the levels of IL-6, IL-18, TNF-αand CH50 were found between male and female patients (P>0.05). Conclusion The changes of CH50 and certain proinflammatory cytokines such as IL-6, IL-18 and TNF-αmight be involved in the progression of MDD , suggesting the possibility of using them as indicators for the di-agnosis of MDD.