中华耳科学杂志
中華耳科學雜誌
중화이과학잡지
CHINESE JOURNAL OF OTOLOGY
2014年
4期
680-683
,共4页
激光%耳显微外科%动物模型
激光%耳顯微外科%動物模型
격광%이현미외과%동물모형
Laser%Otomicrosurgery%Animal model
目的：重点探讨激光耳显微外科动物模型建立过程中如何选择最佳的麻醉方式、手术入路及激光种类。方法选用健康雄性听力正常的豚鼠70只，随机分为A组、B组及C组，其中A、B组各20只，C组30只，分别以速眠新、氯胺酮及复合麻醉，比较三组动物的存活率，并随机观察每组10只豚鼠麻醉后的苏醒时间，然后选用平对外耳道口的耳后入路打开听泡后壁暴露耳蜗底周和圆窗龛，采用CO2激光进行耳蜗底周造孔。结果C组（复合麻醉组）动物存活率最高（p<a′（0.0125）），且该组动物麻醉苏醒时间最短（31.50±7.47min），平对外耳道口的耳后入路损伤小、出血少，易于暴露耳蜗底周及圆窗龛，从而满足CO2激光耳蜗底周造孔的需要。结论在激光耳显微外科动物模型建立的过程中，复合麻醉是最佳的麻醉方式，平对外耳道口的耳后入路是最佳的术式，CO2激光是近年来研究的热点。
目的：重點探討激光耳顯微外科動物模型建立過程中如何選擇最佳的痳醉方式、手術入路及激光種類。方法選用健康雄性聽力正常的豚鼠70隻，隨機分為A組、B組及C組，其中A、B組各20隻，C組30隻，分彆以速眠新、氯胺酮及複閤痳醉，比較三組動物的存活率，併隨機觀察每組10隻豚鼠痳醉後的囌醒時間，然後選用平對外耳道口的耳後入路打開聽泡後壁暴露耳蝸底週和圓窗龕，採用CO2激光進行耳蝸底週造孔。結果C組（複閤痳醉組）動物存活率最高（p<a′（0.0125）），且該組動物痳醉囌醒時間最短（31.50±7.47min），平對外耳道口的耳後入路損傷小、齣血少，易于暴露耳蝸底週及圓窗龕，從而滿足CO2激光耳蝸底週造孔的需要。結論在激光耳顯微外科動物模型建立的過程中，複閤痳醉是最佳的痳醉方式，平對外耳道口的耳後入路是最佳的術式，CO2激光是近年來研究的熱點。
목적：중점탐토격광이현미외과동물모형건립과정중여하선택최가적마취방식、수술입로급격광충류。방법선용건강웅성은력정상적돈서70지，수궤분위A조、B조급C조，기중A、B조각20지，C조30지，분별이속면신、록알동급복합마취，비교삼조동물적존활솔，병수궤관찰매조10지돈서마취후적소성시간，연후선용평대외이도구적이후입로타개은포후벽폭로이와저주화원창감，채용CO2격광진행이와저주조공。결과C조（복합마취조）동물존활솔최고（p<a′（0.0125）），차해조동물마취소성시간최단（31.50±7.47min），평대외이도구적이후입로손상소、출혈소，역우폭로이와저주급원창감，종이만족CO2격광이와저주조공적수요。결론재격광이현미외과동물모형건립적과정중，복합마취시최가적마취방식，평대외이도구적이후입로시최가적술식，CO2격광시근년래연구적열점。
Objective The aim is to determine appropriate anesthetic and surgical approaches and optimal type of laser in an animal model of laser otomicrosurgery. Methods Seventy male guinea pigs with normal hearing were divided into groups A, B and C (n=20 in groups A and B,and n=30 in group C). Animals received anesthesia with either SU MIAN XIN (Group A), ketamine (Group B) or compound anesthesia (Group C). The survival rate was compared between groups, as well as the anesthesia recovery time of ten guinea pigs in each group. The bulla was opened to expose the basal turn of the cochlea and round window niche via a postauricular approach parallel to the external auditory canal. Fenestration on the basal turn was performed with CO2 laser. Results Group C showed the highest survival rate(p<a′ 0.0125)and shortest anesthesia recov?ery time(31.50±7.47min). The postauricular approach resulted in minimal tissue damage and bleeding, and led to easy expo?sure of the basal turn and round window niche,adequate for fenestration in the basal turn CO2 laser. Conclusions In establish?ing this animal model of laser otomicrosurgery, compound anesthesia appears to be the safest anesthesia approch, with a post?auricular approach parallel to the external auditory canal providing a perfect approach for operation, CO2 laser has become the focus of laser otomicrosurgery in recent years.
