CAJ | 학술논문

目的：探讨宫颈小细胞神经内分泌癌（ small cell neuroendocrine carcinoma of the cervix ， SCNEC ）的临床病理特征和免疫组化特点。方法对四川省妇幼保健院病理科和四川省人民医院病理科2006年1月至2014年6月诊治的8例宫颈小细胞神经内分泌癌进行组织形态学、免疫组化观察，并对其临床资料进行整理分析。结果8例患者平均年龄45.6岁，均以阴道不规则出血或宫颈接触性出血就诊。组织学显示肿瘤由大小较为一致的圆形、卵圆形细胞构成。其中单纯性小细胞神经内分泌癌7例，合并腺癌成分1例。免疫组化：所有病例癌细胞细胞角蛋白（ CK）不同程度阳性，且均有两种以上神经内分泌标记阳性，其中6例突触素（Syn）和嗜铬素（CgA）均阳性，4例神经细胞黏附分子（CD56）阳性。随访7例患者，死亡3例。结论宫颈小细胞癌作为一种少见的高度恶性肿瘤，进展快，预后差，免疫组化神经内分泌标志阳性有助于诊断。
목적：탐토궁경소세포신경내분비암（ small cell neuroendocrine carcinoma of the cervix ， SCNEC ）적림상병리특정화면역조화특점。방법대사천성부유보건원병이과화사천성인민의원병이과2006년1월지2014년6월진치적8례궁경소세포신경내분비암진행조직형태학、면역조화관찰，병대기림상자료진행정리분석。결과8례환자평균년령45.6세，균이음도불규칙출혈혹궁경접촉성출혈취진。조직학현시종류유대소교위일치적원형、란원형세포구성。기중단순성소세포신경내분비암7례，합병선암성분1례。면역조화：소유병례암세포세포각단백（ CK）불동정도양성，차균유량충이상신경내분비표기양성，기중6례돌촉소（Syn）화기락소（CgA）균양성，4례신경세포점부분자（CD56）양성。수방7례환자，사망3례。결론궁경소세포암작위일충소견적고도악성종류，진전쾌，예후차，면역조화신경내분비표지양성유조우진단。
Objective To investigate the histopathologic and immunohistochemical characteristics of small cell neuroendocrine carcinoma (SCNEC) in the cervix.Methods Morphologic and immunohistochemical techniques and related clinical data of 8 cases with small cell neuroendocrine carcinoma of the cervix (SCNEC) in Department of pathology, Sichuan Provincial Hospital for Women and Children and Sichuan Academy of Medical Sciences&Sichuan Provincial People’ s Hospital were analyzed .Results The average of 8 cases age was 45.6 years old, and the main symptoms were vaginal bleeing or cervical contactive bleeding .Microscopically, all tumors were composed of small -sized cells in uniformity .7 cases were pure SCNEC , 1 case accompanied with adenocarcinoma . Immunohistochemically , all the tumors were positive to CK , 6 cases were positive to Syn and CgA , and 4 cases were positive to CD56. Follow-up revealed death in 3 cases.Conclusion SCNEC is a rare malignant tumor in the cervix .It is aggressive with a poor prognosis.Immunohistological staining is helpful in diagnosis of SCNEC.