中国民族民间医药
中國民族民間醫藥
중국민족민간의약
CHINESE JOURNAL OF ETHNOMEDICINE AND ETHNOPHARMACY
2015年
1期
42-43
,共2页
朱雪钦%韩静%胡娟%庞文生
硃雪欽%韓靜%鬍娟%龐文生
주설흠%한정%호연%방문생
补阳还五汤%MCAO 大鼠模型%SOD%GST%GSH-PX%MDA
補暘還五湯%MCAO 大鼠模型%SOD%GST%GSH-PX%MDA
보양환오탕%MCAO 대서모형%SOD%GST%GSH-PX%MDA
Buyang huanwu tang%Cerebral Ischemia -Reperfusion Injury%SOD%GST%GSH -PX%MDA
目的：探讨补阳还五汤对大鼠局灶性脑缺血再灌注损伤的保护作用。方法：采用线栓法制造大鼠局灶性脑缺血再灌注模型，给药组给予补阳还五汤原方剂量的水煎液，每日一次，连续灌胃7d；模型组与假手术组均给予同体积生理盐水。测定 SOD、GST 和GSH －PX 活性以及血清中 MDA 含量。结果：补阳还五汤可以显著提高脑缺血再灌注大鼠 SOD、GST、GSH －PX 的活性，明显抑制 MDA 的生成。结论：补阳还五汤对脑缺血再灌注损伤具有明显的保护作用，抗氧化作用是其发挥脑缺血保护作用的机制之一。
目的：探討補暘還五湯對大鼠跼竈性腦缺血再灌註損傷的保護作用。方法：採用線栓法製造大鼠跼竈性腦缺血再灌註模型，給藥組給予補暘還五湯原方劑量的水煎液，每日一次，連續灌胃7d；模型組與假手術組均給予同體積生理鹽水。測定 SOD、GST 和GSH －PX 活性以及血清中 MDA 含量。結果：補暘還五湯可以顯著提高腦缺血再灌註大鼠 SOD、GST、GSH －PX 的活性，明顯抑製 MDA 的生成。結論：補暘還五湯對腦缺血再灌註損傷具有明顯的保護作用，抗氧化作用是其髮揮腦缺血保護作用的機製之一。
목적：탐토보양환오탕대대서국조성뇌결혈재관주손상적보호작용。방법：채용선전법제조대서국조성뇌결혈재관주모형，급약조급여보양환오탕원방제량적수전액，매일일차，련속관위7d；모형조여가수술조균급여동체적생리염수。측정 SOD、GST 화GSH －PX 활성이급혈청중 MDA 함량。결과：보양환오탕가이현저제고뇌결혈재관주대서 SOD、GST、GSH －PX 적활성，명현억제 MDA 적생성。결론：보양환오탕대뇌결혈재관주손상구유명현적보호작용，항양화작용시기발휘뇌결혈보호작용적궤제지일。
Objective To investigate the protection and mechanism of Buyang huanwu tang on focal cerebral in rats.Methods Fo-cal cerebral ischemia -reperfusion model was made with sutur -occluded method in rats.Dose group was given Buyang huanwu tang, Model group and Sham group were given physiological saline.Then they were given once a day for seven consecutive days.The vol-ume of cerebral in farction,the level of MDA in serum,the activities of SOD 、GST and GSH -Px in serum were rileasured.Results Buyang huanwu tang could increase the activities of SOD、GST and GSH -Px in serum and decrease MDA level.Conclosion Buyang huanwu tang has significant protection again cerebral ischemia -reperfusion injury.This effect may be related to its antioxidant proper-ty.
