CAJ | 학술논문

目前全球糖尿病视网膜病变（DR）患者约9300万，其中增殖性DR（PDR）患者1700万，糖尿病性黄斑水肿（DME）患者2100万，威胁视力的DR患者2800万。随着年龄的增长，DME现已成为糖尿病患者视力损害的主要原因。其发病机制尚未明确，研究显示视网膜内、外屏障的破坏等在DME的发生发展中起到重要作用。目前，DME的治疗方法包括传统的激光光凝、糖皮质激素的应用、抗血管内皮生长因子（VEGF）药物的玻璃体腔注射、蛋白激酶C抑制剂的应用、玻璃体手术等，但每种疗法都有其优点和不足。联合治疗重复次数少、疗效高、安全性强，是未来发展的新趋势。本文对老年性DME治疗的国内外研究现状及发展趋势进行综述。
목전전구당뇨병시망막병변（DR）환자약9300만，기중증식성DR（PDR）환자1700만，당뇨병성황반수종（DME）환자2100만，위협시력적DR환자2800만。수착년령적증장，DME현이성위당뇨병환자시력손해적주요원인。기발병궤제상미명학，연구현시시망막내、외병장적파배등재DME적발생발전중기도중요작용。목전，DME적치료방법포괄전통적격광광응、당피질격소적응용、항혈관내피생장인자（VEGF）약물적파리체강주사、단백격매C억제제적응용、파리체수술등，단매충요법도유기우점화불족。연합치료중복차수소、료효고、안전성강，시미래발전적신추세。본문대노년성DME치료적국내외연구현상급발전추세진행종술。
There are about 93 million patients with diabetic retinopathy (DR) all over the world. Among them, 17 million are proliferative DR, 21 million have diabetic macular edema (DME), and 28 million have a threat of vision loss. With aging, DME has become a main cause of vision loss in the patients suffering from diabetes mellitus. Though its pathogenesis is not clear yet, evidence shows that break-down of the inner and outer blood-retinal barrier might be involved in the incidence and development of DME. At present, the treating methods of DME include retinal laser photocoagulation, application of glucocorticoids, intravitreous injection of anti-vascular endothelial growth factor (VEGF), administration of inhibitor of protein kinase C, vitrectomy, etc. However, each method has its advantages and disadvantages. The combined treatment has a bright future for its fewer repetitions, higher efficacy and great safety. In this paper, we reviewed current research status and future development trends of DME treatment for the elderly.