CAJ | 학술논문

目的：研究避光输液器在临床输注过程中与药物的相互作用以及安全性问题。方法通过对硝普钠、氟罗沙星以及盐酸阿扎司琼3种光敏性药物用避光输液器进行模拟临床输液试验，对流经输液器前后的药液的各项指标进行检测，并对增塑剂TOTM以及避光着色剂在输液过程中的迁移进行检测。结果药物溶液在光照条件下经过避光输液器前后各项指标并无明显变化。增塑剂TOTM与避光着色剂在输液过程中有微量溶出。结论避光输液器与试验药物相容性良好，输液管路中的TOTM与避光着色剂有微量溶出，应用一次性避光式输液器输注光敏感型药物安全可靠。
목적：연구피광수액기재림상수주과정중여약물적상호작용이급안전성문제。방법통과대초보납、불라사성이급염산아찰사경3충광민성약물용피광수액기진행모의림상수액시험，대류경수액기전후적약액적각항지표진행검측，병대증소제TOTM이급피광착색제재수액과정중적천이진행검측。결과약물용액재광조조건하경과피광수액기전후각항지표병무명현변화。증소제TOTM여피광착색제재수액과정중유미량용출。결론피광수액기여시험약물상용성량호，수액관로중적TOTM여피광착색제유미량용출，응용일차성피광식수액기수주광민감형약물안전가고。
OBJECTIVE To discuss the interaction between drugs and the light-resistant infusion sets in the process of clinical infusion for the safety evaluation and drug Compatibility test .METHODS Three light-sensitive drugs( Sodium Nitroprusside , Fleroxacin and Azasetron Hydrochloride ) were used to simulate clinical operation by lightproof infusion device ,and various targets of the drug before and after infusing and the release of the plasticizer TOTM and the light-resistant colorants had also been determinated .RESULTS No obvious changes can be observed in the drug solution before and after the infusion process ,with trace plasticizer TOTM and the light-resistant colorants released.CONCLUSION The light-resistant infusion sets are effective and compatible with the drugs .The trace re-lease of plasticizer and light-resistant colorantsit proves the safety of light-resistant infusion sets for clinical operation .