CAJ | 학술논문

目的：探讨梅毒晚期麻痹性痴呆患者的脑电图特征及其诊断价值。方法选取2011年5月至2013年12月首都医科大学附属北京地坛医院神经内科收治的麻痹性痴呆患者11例和同期健康对照组11例做为研究对象。在Matlab 7.0平台上对脑电信号进行频谱分析，分别计算各导联（Fp1、Fp2、F3、F4、C3、C4、P3、P4、O1、O2、F7、F8、T3、T4、T5、T6）各频带（δ、θ、α、β、γ频带）的相对功率比、α/θ值及左右半球间的相应导联（Fp1-Fp2、F3-F4、C3-C4、P3-P4、O1-O2、F7-F8、T3-T4、T5-T6）各频带（δ、θ、α、β、γ频带）的最大相干值及其对应频率。结果在相对功率比的比较中，麻痹性痴呆患者较对照组慢波频带（δ、θ频带）升高（P分别＜0.05、＜0.01和＜0.001），快波频带（α、β、γ频带）降低（P分别＜0.05、＜0.01和＜0.001）；在双额、双枕、右额、右颞及左顶区麻痹性痴呆组α/θ值降低（P分别＜0.05和＜0.01）；额顶区γ频带、顶区β频带、枕区α频带和颞区θ频带的最大相干值及顶区α频带，枕区β频带，颞区θ、γ、δ频带的对应频率较对照组降低（P分别＜0.05和＜0.01）。结论麻痹性痴呆患者的脑电慢波频带呈升高趋势，快波频带呈降低趋势，左右半球间相应导联频带的最大相干值及对应频率减低，可为诊断提供有力的客观依据。
목적：탐토매독만기마비성치태환자적뇌전도특정급기진단개치。방법선취2011년5월지2013년12월수도의과대학부속북경지단의원신경내과수치적마비성치태환자11례화동기건강대조조11례주위연구대상。재Matlab 7.0평태상대뇌전신호진행빈보분석，분별계산각도련（Fp1、Fp2、F3、F4、C3、C4、P3、P4、O1、O2、F7、F8、T3、T4、T5、T6）각빈대（δ、θ、α、β、γ빈대）적상대공솔비、α/θ치급좌우반구간적상응도련（Fp1-Fp2、F3-F4、C3-C4、P3-P4、O1-O2、F7-F8、T3-T4、T5-T6）각빈대（δ、θ、α、β、γ빈대）적최대상간치급기대응빈솔。결과재상대공솔비적비교중，마비성치태환자교대조조만파빈대（δ、θ빈대）승고（P분별＜0.05、＜0.01화＜0.001），쾌파빈대（α、β、γ빈대）강저（P분별＜0.05、＜0.01화＜0.001）；재쌍액、쌍침、우액、우섭급좌정구마비성치태조α/θ치강저（P분별＜0.05화＜0.01）；액정구γ빈대、정구β빈대、침구α빈대화섭구θ빈대적최대상간치급정구α빈대，침구β빈대，섭구θ、γ、δ빈대적대응빈솔교대조조강저（P분별＜0.05화＜0.01）。결론마비성치태환자적뇌전만파빈대정승고추세，쾌파빈대정강저추세，좌우반구간상응도련빈대적최대상간치급대응빈솔감저，가위진단제공유력적객관의거。
Objective To investigate the electroencephalographic characteristics and diagnostic value of general paresis of insane (GPI) in the late stage of syphilis. Methods The contrast researches were made between GPI group with patients in Department of Neurology, Beijing Ditan Hospital, Capital Medical University from May 2011 to December 2013 while the normal control group with health people at the same time, each with 11 individuals.The EEG signal frequency spectrum analyses were based on the platform of MATLAB 7.0, and were calculated out the relative frequency band power percentage (RFBPP) of each frequency band (including frequency bandδ,θ,α,βandγ) of each lead (including lead Fp1, Fp2, F3, F4, C3, C4, P3, P4, O1, O2, F7, F8, T3, T4, T5 and T6), the power ratio ofαband toθband (the ratio ofα/θ) and the largest coherence value in the corresponding frequency band between left and right hemispheres. Results In the comparison of RFBPP, the low frequency band (δ-θband) of patients with GPI increased than the control group (P<0.05,<0.01 and<0.001), whereas the high frequency band (α-γband) decreased (P<0.05,<0.01 and<0.001). The ratio ofα/θin bilateral frontal, bilateral occipital, right frontal, right temporal and left parietal regions were lower than the normal controls (P<0.05 and<0.01). The EEG coherence value (CohV) between bilateral brains of GPI patients declined in frontal, temporal, occipital and parietal regions inθ,α,βandγfrequency band, meanwhile, the corresponding frequency band decreased in temporal, parietal and occipital regions (P<0.05 and P<0.01). Conclusions It could provide important evidence for diagnosis that the RFBPP of GPI group in low frequency band power increased, on the contrary, it decreased in high frequency band power, furthermore, the coherence value in the corresponding band between bilateral brains also fell.