中华实验和临床感染病杂志(电子版)
中華實驗和臨床感染病雜誌(電子版)
중화실험화림상감염병잡지(전자판)
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL INFECTIOUS DISEASES(ELECTRONIC VERSION)
2014年
6期
827-829
,共3页
非淋球菌性尿道炎%支原体%药敏%耐药性
非淋毬菌性尿道炎%支原體%藥敏%耐藥性
비림구균성뇨도염%지원체%약민%내약성
Non-gonococcal urethritis%Mycoplasma%Drug susceptibility%Drug resistance
目的:探讨非淋菌性尿道炎(NGU)患者支原体感染及耐药性,为临床诊疗及合理用药提供一定的依据。方法对2013年8月至2014年2月于上海长征医院收治的897例NGU患者进行解脲支原体(Uu)和人支原体(Mh)培养鉴定,并对阳性标本进行12种抗菌药物药敏试验。结果897例NGU患者支原体培养阳性420例,阳性率为46.82%(420/897),其中Uu阳性率为34.89%(313/897),Mh阳性率为2%(18/897),Uu+Mh阳性率为9.92%(89/897);女性患者Uu阳性率和Uu+Mh阳性率分别为46.60%(233/500)和13.20%(66/500),均显著高于男性的20.15%(80/397)和5.79%(23/397)(χ2值分别为68.14和13.59,P <0.05);支原体对12种抗菌药物敏感性较强的是交沙霉素、美满霉素、强力霉素和四环素,敏感率分别为94.05%(395/420)、92.86%(390/420)、92.62%(389/420)和89.29%(375/420),而对诺氟沙星、阿奇霉素和红霉素的耐药性均较高,耐药率分别为87.38%(367/420)、73.33%(308/420)和71.19%(299/420)。结论 NGU患者支原体感染以Uu和Uu+Mh混合感染为主,且耐药性严重。临床中对NGU的治疗应根据药敏结果合理使用抗菌药物,以减少耐药菌株的产生。
目的:探討非淋菌性尿道炎(NGU)患者支原體感染及耐藥性,為臨床診療及閤理用藥提供一定的依據。方法對2013年8月至2014年2月于上海長徵醫院收治的897例NGU患者進行解脲支原體(Uu)和人支原體(Mh)培養鑒定,併對暘性標本進行12種抗菌藥物藥敏試驗。結果897例NGU患者支原體培養暘性420例,暘性率為46.82%(420/897),其中Uu暘性率為34.89%(313/897),Mh暘性率為2%(18/897),Uu+Mh暘性率為9.92%(89/897);女性患者Uu暘性率和Uu+Mh暘性率分彆為46.60%(233/500)和13.20%(66/500),均顯著高于男性的20.15%(80/397)和5.79%(23/397)(χ2值分彆為68.14和13.59,P <0.05);支原體對12種抗菌藥物敏感性較彊的是交沙黴素、美滿黴素、彊力黴素和四環素,敏感率分彆為94.05%(395/420)、92.86%(390/420)、92.62%(389/420)和89.29%(375/420),而對諾氟沙星、阿奇黴素和紅黴素的耐藥性均較高,耐藥率分彆為87.38%(367/420)、73.33%(308/420)和71.19%(299/420)。結論 NGU患者支原體感染以Uu和Uu+Mh混閤感染為主,且耐藥性嚴重。臨床中對NGU的治療應根據藥敏結果閤理使用抗菌藥物,以減少耐藥菌株的產生。
목적:탐토비림균성뇨도염(NGU)환자지원체감염급내약성,위림상진료급합리용약제공일정적의거。방법대2013년8월지2014년2월우상해장정의원수치적897례NGU환자진행해뇨지원체(Uu)화인지원체(Mh)배양감정,병대양성표본진행12충항균약물약민시험。결과897례NGU환자지원체배양양성420례,양성솔위46.82%(420/897),기중Uu양성솔위34.89%(313/897),Mh양성솔위2%(18/897),Uu+Mh양성솔위9.92%(89/897);녀성환자Uu양성솔화Uu+Mh양성솔분별위46.60%(233/500)화13.20%(66/500),균현저고우남성적20.15%(80/397)화5.79%(23/397)(χ2치분별위68.14화13.59,P <0.05);지원체대12충항균약물민감성교강적시교사매소、미만매소、강력매소화사배소,민감솔분별위94.05%(395/420)、92.86%(390/420)、92.62%(389/420)화89.29%(375/420),이대낙불사성、아기매소화홍매소적내약성균교고,내약솔분별위87.38%(367/420)、73.33%(308/420)화71.19%(299/420)。결론 NGU환자지원체감염이Uu화Uu+Mh혼합감염위주,차내약성엄중。림상중대NGU적치료응근거약민결과합리사용항균약물,이감소내약균주적산생。
Objective To investigate the drug resistance of mycoplasma infections in the patients with non-gonococcal urethritis (NGU), and provide instructions for the clinical treatment and reasonable use of antibiotics. Methods Ureaplasma urealyticum (Uu) and mycoplasma hominis (Mh) in 897 patients with NGU who enrolled in Shanghai Changzheng Hospital from August 2013 to February 2014 were cultured and tested, and the drug susceptibility test for 12 antibiotics were performed, respectively. Results Among the 897 patients with NGU, 420 cases were positive in mycoplasma culture, and the positive rate was 46.82%(420/897), the positive rate of Uu was 34.89% (313/897), the positive rate of Mh was 2% (18/897), the positive rate of (Uu+Mh) was 9.92%(89/897). The positive rate of Uu of the female patients was 46.60%(233/500), signiifcantly higher than 20.15%(80/397) of the male patients (χ2=68.14 ,P<0.05). The positive rate of (Uu+Mh) of the female patients was 13.20%(66/500), signiifcantly higher than 5.79%(23/397) of the male patients (χ2=13.59 ,P<0.05). Among the twelve commonly used antibiotics, the mycoplasma were highly susceptible to josamycin (94.05%, 395/420), minocycline (92.86%, 390/420), doxycycline (92.62%, 389/420) and tetracycline (89.29%, 375/420), were highly resistant to norfloxacin (87.38%, 367/420), azitromycin (73.33%, 308/420) and erythromycin (71.19%, 299/420). Conclusions Uu and (Uu+Mh) are dominant in the mycoplasma infections in patients with NGU and with highly drug-resistant. It is necessary for the hospital to reasonably use antibiotics to treat the patients with NGU and based on the results of drug susceptibility testing so as to reduce the drug resistant strains.