皖南医学院学报
皖南醫學院學報
환남의학원학보
ACTA ACADEMIAE MEDICINAE WANNAN
2015年
1期
36-38
,共3页
戴艳%方芳%冯钢%苏贵平%黄来全%蒋艺枝%黄东平
戴豔%方芳%馮鋼%囌貴平%黃來全%蔣藝枝%黃東平
대염%방방%풍강%소귀평%황래전%장예지%황동평
造血干细胞移植%人巨细胞病毒%更昔洛韦
造血榦細胞移植%人巨細胞病毒%更昔洛韋
조혈간세포이식%인거세포병독%경석락위
hematopoietic stem cell transplantation%cytomegalovirus%ganciclovir
目的:探讨分析造血干细胞移植(hematopoietic stem cell transplantation ,HSCT)后人巨细胞病毒(HCMV)感染与更昔洛韦(ganciclovir,GCV)耐药的发生及与移植类型、移植物抗宿主病(GVHD)等的相关性。方法:2012年3月~2014年4月在我院接受HSCT的患者18例,采用FQ-PCR法监测HCMV-DNA水平。 HCMV-DNA阳性患者给予GCV抢先治疗。结果:8例患者发生HCMV感染(44.4%),其中7例为不全相合无关供体脐血造血干细胞移植(UCBT)者。发生HCMV感染的8例患者中有7人出现GVHD,其中出现Ⅲ度及以上GVHD有5例(71.4%),均为UCBT者。 GCV耐药2例,均为UCBT后。结论:UCBT患者HCMV感染及GCV耐药高,GVHD与HCMV感染有关。
目的:探討分析造血榦細胞移植(hematopoietic stem cell transplantation ,HSCT)後人巨細胞病毒(HCMV)感染與更昔洛韋(ganciclovir,GCV)耐藥的髮生及與移植類型、移植物抗宿主病(GVHD)等的相關性。方法:2012年3月~2014年4月在我院接受HSCT的患者18例,採用FQ-PCR法鑑測HCMV-DNA水平。 HCMV-DNA暘性患者給予GCV搶先治療。結果:8例患者髮生HCMV感染(44.4%),其中7例為不全相閤無關供體臍血造血榦細胞移植(UCBT)者。髮生HCMV感染的8例患者中有7人齣現GVHD,其中齣現Ⅲ度及以上GVHD有5例(71.4%),均為UCBT者。 GCV耐藥2例,均為UCBT後。結論:UCBT患者HCMV感染及GCV耐藥高,GVHD與HCMV感染有關。
목적:탐토분석조혈간세포이식(hematopoietic stem cell transplantation ,HSCT)후인거세포병독(HCMV)감염여경석락위(ganciclovir,GCV)내약적발생급여이식류형、이식물항숙주병(GVHD)등적상관성。방법:2012년3월~2014년4월재아원접수HSCT적환자18례,채용FQ-PCR법감측HCMV-DNA수평。 HCMV-DNA양성환자급여GCV창선치료。결과:8례환자발생HCMV감염(44.4%),기중7례위불전상합무관공체제혈조혈간세포이식(UCBT)자。발생HCMV감염적8례환자중유7인출현GVHD,기중출현Ⅲ도급이상GVHD유5례(71.4%),균위UCBT자。 GCV내약2례,균위UCBT후。결론:UCBT환자HCMV감염급GCV내약고,GVHD여HCMV감염유관。
Objective:To investigate the incidence of cytomegalovirus ( CMV ) infection and ganciclovir ( GCV ) resistance after hematopoietic stem cell transplantation( HSCT) ,and the correlation between CMV infection and graft-versus-host disease ( GVHD) .Methods:Eighteen patients undergone HSCT in our hospital were included between March 2012 and April 2014.Real-time fluorescent quantitative PCR(FQ-PCR) was performed to test the CMV in-fection in total patients,and patients with positive CMV-DNA were treated with GCV.Results:CMV infection occurred in 8 patients (44.4%),in whom 7 were umbilical cord blood transplantation(UCBT) from unrelated donors(87.5%,7/8).Seven in 8 with CMV infection were complicated with GVHD,in which 5 were infection of gradeⅢor over(71.4%,5 /7).GCV resistance after UCBT occurred in 2.Conclusion:HCMV infection and GCV resistance ap-pear higher in patients after UCBT,and incidence of GVHD is associated with HCMV.