CAJ | 학술논문

目的：通过观察不同组别川崎病（ KD）患儿血浆内皮素（ ET）、一氧化氮（ NO）的水平变化，探讨其临床价值以及与冠状动脉损伤（CALs）的关系。方法：对住院KD患儿常规行心脏超声检查，根据结果分为CALs组（30例）和无CALs组（50例），另选取90例年龄、性别无明显统计差异的同期门诊体检健康儿童作为正常对照组，同时选取同期住院的肺炎患儿40例作为病例对照组。分别采用放射性免疫方法、硝酸还原酶法测得各组血浆ET、NO水平。结果：KD患儿急性期血浆ET、NO均高于正常对照组和病例对照组，差异有统计学意义，治疗后则较正常组无明显统计学差异；CALs组血浆ET、NO均高于NCALs组，P＜0．001。结论：KD患儿ET、NO的水平明显增加，且ET、NO的水平可能与冠脉损伤有关。
목적：통과관찰불동조별천기병（ KD）환인혈장내피소（ ET）、일양화담（ NO）적수평변화，탐토기림상개치이급여관상동맥손상（CALs）적관계。방법：대주원KD환인상규행심장초성검사，근거결과분위CALs조（30례）화무CALs조（50례），령선취90례년령、성별무명현통계차이적동기문진체검건강인동작위정상대조조，동시선취동기주원적폐염환인40례작위병례대조조。분별채용방사성면역방법、초산환원매법측득각조혈장ET、NO수평。결과：KD환인급성기혈장ET、NO균고우정상대조조화병례대조조，차이유통계학의의，치료후칙교정상조무명현통계학차이；CALs조혈장ET、NO균고우NCALs조，P＜0．001。결론：KD환인ET、NO적수평명현증가，차ET、NO적수평가능여관맥손상유관。
Objective:To investigate the level changes of plasmic endothelin(ET) and nitric oxide(NO) in children with Kawasaki disease (KD) for de-termination of the clinical values of the changes and coronary artery lesions (CALs).Methods:By the routine echocardiographic findings,the hospitalized KD children were allocated to group with CALs(n=30) and without CALs (n=50).Ninety healthy subjects(without significant difference in ages and genders) undergone physical examination on out-patient basis were included as healthy controls and another 40 inpatient children with pneumonia underg-one treatment on hospital stay basis were recruited as case controls .Radioimmunoassay and nitrate reductase methods were used to measure the plasma ET and NO levels in each group described above.Results:Higher plasma levels of ET and NO were seen in KD children in their acute stage than the healthy controls and case controls,and the difference was significant,whereas the difference was not after treatment as compared with the healthy controls.Plasma ET and NO levels were higher in children with CALs than those without CALs(P<0.001).Conclusion:Plasma levels of ET and NO tend to significantly elevate in KD children,suggesting that changes of ET and NO levels may be associated with coronary artery lesion .