皖南医学院学报
皖南醫學院學報
환남의학원학보
ACTA ACADEMIAE MEDICINAE WANNAN
2015年
1期
26-29
,共4页
朱琼%张道友%李娟%汪裕伟%高潮清%杨沿浪%杨利才%葛俊%张胜楠
硃瓊%張道友%李娟%汪裕偉%高潮清%楊沿浪%楊利纔%葛俊%張勝楠
주경%장도우%리연%왕유위%고조청%양연랑%양리재%갈준%장성남
心肾综合征%脑钠肽%胱抑素C%超声心动图
心腎綜閤徵%腦鈉肽%胱抑素C%超聲心動圖
심신종합정%뇌납태%광억소C%초성심동도
cardiorenal syndrome%brain natriuretic peptide%cystatin C%color doppler ultrasound
目的:探讨心肾综合征( cardiorenal syndrome , CRS )患者超声心动图变化及全血脑钠肽( brain natriuretic peptide , BNP)、胱抑素C(Cystatin C,Cys-C)水平等与慢性肾脏病(chronic kidney disease,CKD)分期的关系。方法:我院肾内科符合标准的84例CRS患者,检测入院时的全血BNP、Cys-C水平,并检测超声心动图及心电图,收集相关参数进行分析。结果:CKD3、45、期CRS患者之间,全血BNP、Cys-C水平有显著差异,各组之间左室舒张末期内径( LVDd)、左室后壁厚度( LVPW)、E峰、E/A、心率差异有统计学意义( P<0.05),而BNP和LVDd与CKD分期的相关性更加密切。结论:CKD 3~5期CRS患者心脏结构改变主要表现在左室舒张末期内径、左室后壁厚度增加等,心功能障碍主要表现在舒张功能受累。联合全血BNP、Cys-C水平、超声心动图及心电图检查可以作为观察CRS病情的有效指标,有利于预防及早期治疗。
目的:探討心腎綜閤徵( cardiorenal syndrome , CRS )患者超聲心動圖變化及全血腦鈉肽( brain natriuretic peptide , BNP)、胱抑素C(Cystatin C,Cys-C)水平等與慢性腎髒病(chronic kidney disease,CKD)分期的關繫。方法:我院腎內科符閤標準的84例CRS患者,檢測入院時的全血BNP、Cys-C水平,併檢測超聲心動圖及心電圖,收集相關參數進行分析。結果:CKD3、45、期CRS患者之間,全血BNP、Cys-C水平有顯著差異,各組之間左室舒張末期內徑( LVDd)、左室後壁厚度( LVPW)、E峰、E/A、心率差異有統計學意義( P<0.05),而BNP和LVDd與CKD分期的相關性更加密切。結論:CKD 3~5期CRS患者心髒結構改變主要錶現在左室舒張末期內徑、左室後壁厚度增加等,心功能障礙主要錶現在舒張功能受纍。聯閤全血BNP、Cys-C水平、超聲心動圖及心電圖檢查可以作為觀察CRS病情的有效指標,有利于預防及早期治療。
목적:탐토심신종합정( cardiorenal syndrome , CRS )환자초성심동도변화급전혈뇌납태( brain natriuretic peptide , BNP)、광억소C(Cystatin C,Cys-C)수평등여만성신장병(chronic kidney disease,CKD)분기적관계。방법:아원신내과부합표준적84례CRS환자,검측입원시적전혈BNP、Cys-C수평,병검측초성심동도급심전도,수집상관삼수진행분석。결과:CKD3、45、기CRS환자지간,전혈BNP、Cys-C수평유현저차이,각조지간좌실서장말기내경( LVDd)、좌실후벽후도( LVPW)、E봉、E/A、심솔차이유통계학의의( P<0.05),이BNP화LVDd여CKD분기적상관성경가밀절。결론:CKD 3~5기CRS환자심장결구개변주요표현재좌실서장말기내경、좌실후벽후도증가등,심공능장애주요표현재서장공능수루。연합전혈BNP、Cys-C수평、초성심동도급심전도검사가이작위관찰CRS병정적유효지표,유리우예방급조기치료。
Objective:To explore the relationship between the staging of chronic kidney disease ( CKD) and changes of heart structure and brain natriuret-ic peptide(BNP) and cystatin C(Cys-C) in patients with cardiorenal syndrome(CRS).Methods:Total of 84 eligible patients with CKD were included be -tween January 2011and June 2012.All patients were undergone determination of whole blood BNP and cys -C levels as well as echocardiogram and electro-cardiogram examination at admission.The data were gathered for analysis of the relationship among the indicators .Rseult s:Of the patients in stage of CKD 3,4 and 5,the BNP and cys-C levels,left ventricular end diastolic diameter(LVDd),left ventricular posterior wall thickness(LVPW),and flow velocity at peak E and E/A ratio were statistically different(P<0.01).Conclusion:CRS patients in stage CKD 3 to 5 primarily demonstrated LVDd change and thickened posterior left ventricular wall and diastolic function impairment .Combined determination of whole blood BNP and cys-C with echocardiogram and electrocardiogram examination may be effective indicators for prevention and early treatment of this disease .