皖南医学院学报
皖南醫學院學報
환남의학원학보
ACTA ACADEMIAE MEDICINAE WANNAN
2015年
1期
6-9
,共4页
宗巧凤%张冠军%于影%李正红
宗巧鳳%張冠軍%于影%李正紅
종교봉%장관군%우영%리정홍
内吗啡肽%阿片受体%左心室功能
內嗎啡肽%阿片受體%左心室功能
내마배태%아편수체%좌심실공능
endomorphin%opioid receptor%left ventricular function
目的:观察静脉注射内吗啡肽-1和2(EM-1、EM-2)对大鼠左心室功能的影响,并初步探讨其作用机理。方法:大鼠麻醉后,经右颈总动脉左心室插管测左心室功能( LVSP、HR、±dp/dt等)。颈外静脉注射给药。结果:与对照组比较,静脉注射EM-1、EM-2剂量依赖性地降低麻醉大鼠左心室功能。与EM-1/EM-2+NS组比较,除一氧化氮合成酶抑制剂 L-NNA (25 mg/kg,i.v.)对EM-1降低心率的作用无明显影响外,预先给予纳洛酮(1 mg/kg,i.v.)或阿托品(50μg/kg,i.v.)或L-NNA (25 mg/kg,i.v.),或切断双侧迷走神经均显著减弱EM-1、EM-2降低心功能的作用(P<0.05或P<0.01)。结论:静脉注射EM-1、EM-2可引起麻醉大鼠左心室功能下降,此效应由阿片受体介导,有胆碱能M受体参加,有NO的参与,与迷走神经兴奋有关。
目的:觀察靜脈註射內嗎啡肽-1和2(EM-1、EM-2)對大鼠左心室功能的影響,併初步探討其作用機理。方法:大鼠痳醉後,經右頸總動脈左心室插管測左心室功能( LVSP、HR、±dp/dt等)。頸外靜脈註射給藥。結果:與對照組比較,靜脈註射EM-1、EM-2劑量依賴性地降低痳醉大鼠左心室功能。與EM-1/EM-2+NS組比較,除一氧化氮閤成酶抑製劑 L-NNA (25 mg/kg,i.v.)對EM-1降低心率的作用無明顯影響外,預先給予納洛酮(1 mg/kg,i.v.)或阿託品(50μg/kg,i.v.)或L-NNA (25 mg/kg,i.v.),或切斷雙側迷走神經均顯著減弱EM-1、EM-2降低心功能的作用(P<0.05或P<0.01)。結論:靜脈註射EM-1、EM-2可引起痳醉大鼠左心室功能下降,此效應由阿片受體介導,有膽堿能M受體參加,有NO的參與,與迷走神經興奮有關。
목적:관찰정맥주사내마배태-1화2(EM-1、EM-2)대대서좌심실공능적영향,병초보탐토기작용궤리。방법:대서마취후,경우경총동맥좌심실삽관측좌심실공능( LVSP、HR、±dp/dt등)。경외정맥주사급약。결과:여대조조비교,정맥주사EM-1、EM-2제량의뢰성지강저마취대서좌심실공능。여EM-1/EM-2+NS조비교,제일양화담합성매억제제 L-NNA (25 mg/kg,i.v.)대EM-1강저심솔적작용무명현영향외,예선급여납락동(1 mg/kg,i.v.)혹아탁품(50μg/kg,i.v.)혹L-NNA (25 mg/kg,i.v.),혹절단쌍측미주신경균현저감약EM-1、EM-2강저심공능적작용(P<0.05혹P<0.01)。결론:정맥주사EM-1、EM-2가인기마취대서좌심실공능하강,차효응유아편수체개도,유담감능M수체삼가,유NO적삼여,여미주신경흥강유관。
Objective:To observe the effects of intravenous injection of endomorphin-1(EM-1) and endomorphin-2(EM-2) on the left ventricular function in anesthetized rats,and to primarily investigate its potential mechanism.Methods:The left ventricular function(LVSP,HR, ±dp/dt) were measured by inserting a catheter from right carotid artery into left ventricle after intravenous injection of EM-1 and EM-2 in the anesthetized rats.Results:Compared with control group,EM-1 and EM-2 led to decreased dose-dependent for the left ventricular function.By comparison with EM +NS group,the decrease in left ventricular function was attenuated by pretreatment with intravenous injection of either naloxone(1 mg/kg,i.v.),atropine(50 μg/kg,i.v.),L-NNA(25 mg/kg,i.v.) or bilateral cervical vagotomy.Conclusion:Intravenous administration of EM-1 and EM-2 produced inhibition effect on the left ventricular function in anesthetized rats,and the potential mechanism is associated with mediation of opioid receptor,involvement of M-cholinoceptor and NO as well as vagus nerve excitation.