海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2015年
3期
342-344
,共3页
颜世军%周炳文%黄娜%缪东幸
顏世軍%週炳文%黃娜%繆東倖
안세군%주병문%황나%무동행
川崎病%冠状动脉%巨噬细胞炎症蛋白-1α
川崎病%冠狀動脈%巨噬細胞炎癥蛋白-1α
천기병%관상동맥%거서세포염증단백-1α
Kawasaki disease%Coronary artery%Macrophage inflammatory protein-1α
目的:探讨血清巨噬细胞炎症蛋白-1α(MIP-1α)水平与川崎病(KD)冠脉损伤的相关性。方法选取急性期KD患儿40例,其中15例有冠脉损伤,正常对照组20例。采用酶联免疫法(ELISA)检测血清MIP-1α水平,超声心动图检测冠状动脉扩张程度,分析血清MIP-1α水平变化及其与冠状动脉扩张程度的相关性。结果 KD急性期患儿的血清MIP-1α水平为(79.16±11.54) ng/L,高于正常对照组(38.16±5.21) ng/L,差异有统计学意义(P<0.05);冠脉损伤KD患儿的MIP-1α水平为(89.14±10.52) ng/L,高于无冠脉损伤KD患儿(71.15±2.48) ng/L,差异有统计学意义(P<0.05)。KD患儿血清MIP-1α水平与冠状动脉扩张程度呈正相关(r=0.438,P<0.05)。结论 KD急性期患儿的血清MIP-1α水平明显升高,伴有冠状动脉损伤的KD患儿的水平更高;血清MIP-1α水平与冠状动脉扩张程度呈正相关。
目的:探討血清巨噬細胞炎癥蛋白-1α(MIP-1α)水平與川崎病(KD)冠脈損傷的相關性。方法選取急性期KD患兒40例,其中15例有冠脈損傷,正常對照組20例。採用酶聯免疫法(ELISA)檢測血清MIP-1α水平,超聲心動圖檢測冠狀動脈擴張程度,分析血清MIP-1α水平變化及其與冠狀動脈擴張程度的相關性。結果 KD急性期患兒的血清MIP-1α水平為(79.16±11.54) ng/L,高于正常對照組(38.16±5.21) ng/L,差異有統計學意義(P<0.05);冠脈損傷KD患兒的MIP-1α水平為(89.14±10.52) ng/L,高于無冠脈損傷KD患兒(71.15±2.48) ng/L,差異有統計學意義(P<0.05)。KD患兒血清MIP-1α水平與冠狀動脈擴張程度呈正相關(r=0.438,P<0.05)。結論 KD急性期患兒的血清MIP-1α水平明顯升高,伴有冠狀動脈損傷的KD患兒的水平更高;血清MIP-1α水平與冠狀動脈擴張程度呈正相關。
목적:탐토혈청거서세포염증단백-1α(MIP-1α)수평여천기병(KD)관맥손상적상관성。방법선취급성기KD환인40례,기중15례유관맥손상,정상대조조20례。채용매련면역법(ELISA)검측혈청MIP-1α수평,초성심동도검측관상동맥확장정도,분석혈청MIP-1α수평변화급기여관상동맥확장정도적상관성。결과 KD급성기환인적혈청MIP-1α수평위(79.16±11.54) ng/L,고우정상대조조(38.16±5.21) ng/L,차이유통계학의의(P<0.05);관맥손상KD환인적MIP-1α수평위(89.14±10.52) ng/L,고우무관맥손상KD환인(71.15±2.48) ng/L,차이유통계학의의(P<0.05)。KD환인혈청MIP-1α수평여관상동맥확장정도정정상관(r=0.438,P<0.05)。결론 KD급성기환인적혈청MIP-1α수평명현승고,반유관상동맥손상적KD환인적수평경고;혈청MIP-1α수평여관상동맥확장정도정정상관。
Objective To investigate the relationship between serum MIP-1αlevel and coronary artery le-sion in Kawasaki disease (KD). Methods The levels of serum MIP-1αfrom 40 KD patients (including 15 patients with coronary artery lesion) and 20 healthy children were detected by enzyme-linked immunosorbent assay. The de-gree of coronary artery dilatation was detected by ultrasonic cardiogram and its association with MIP-1α was ana-lyzed. Results The level of serum MIP-1αin acute KD patients (79.16 ± 11.54) ng/L was significantly higher than that in healthy children (38.16 ± 5.21) ng/L (P<0.05). The level of serum MIP-1αin acute KD patients with coronary artery lesion (89.14±10.52) ng/L was higher than in KD patients with non-coronary artery dilatation (71.15±2.48) ng/L (P<0.05). In addition, the level of serum MIP-1αin KD patients showed positive correlation with the degree of coro-nary artery dilatation (r=0.438, P<0.05). Conclusion The level of serum MIP-1αis significantly higher in KD pa-tients and further higher in KD patients with coronary artery lesion. The serum MIP-1αlevel in KD patients shows a positive correlation with the degree of coronary artery dilatation.