CAJ | 학술논문

慢性缺氧是许多呼吸系统疾病常见的病理和生理过程。低氧性肺动脉高压是一种长期暴露在低氧环境中所诱发的渐进性、复杂性病变，它最终导致不可逆转的右心衰竭，因此成为临床治疗的难点。肺血管重塑是肺动脉高压不断进展的病理基础，亦是多种药物治疗不理想的根源。肺血管重塑机制复杂，其中涉及到多种细胞分子和信号通道的分别和相互作用，对其全面了解有着重要的意义。本文就目前的研究现状和研究前景做一综述。
만성결양시허다호흡계통질병상견적병리화생리과정。저양성폐동맥고압시일충장기폭로재저양배경중소유발적점진성、복잡성병변，타최종도치불가역전적우심쇠갈，인차성위림상치료적난점。폐혈관중소시폐동맥고압불단진전적병리기출，역시다충약물치료불이상적근원。폐혈관중소궤제복잡，기중섭급도다충세포분자화신호통도적분별화상호작용，대기전면료해유착중요적의의。본문취목전적연구현상화연구전경주일종술。
Chronic hypoxia is a common pathological and physiological characteristic of many respiratory dis-eases. A long-time exposure in the low oxygen environment could induce hypoxic pulmonary hypertension (HPH), which is a progressive and complex process. And it became a difficult point of clinical treatment for its leading to an ir-reversible right heart failure. Hypoxia-induced pulmonary vascular remodeling is the pathological basis of progressive HPH and the main reason for the dissatisfied drug treatment. It is of great significance for a further study of the cellular and molecular mechanisms of hypoxia-induced remodeling which showed a highly complex process where numerous in-teractive events existed. And the review herewith provides a summary on the research status and its prospects.