CAJ | 학술논문

目的：探讨派特CT (PET-CT)在食管癌放疗靶区勾画中的应用价值。方法选取2013年1月至2014年1月收治的60例食管癌患者为研究对象，根据其放疗靶区勾画方式的不同分为对照组(以CT进行定位及勾画放疗靶区)30例和观察组(以PET-CT进行定位及勾画放疗靶区)30例，比较两组患者放射性肺损伤发生率及放射治疗前和放射治疗后1周、2周、4周、6周的血清转化生长因子-β1(TGF-β1)、肿瘤坏死因子α(TNF-α)、白介素1β(IL-1β)及基质金属蛋白酶12(MMP-12)水平。结果观察组中不同部位病灶者的放射性肺损伤发生率均低于对照组，放射治疗后1周、2周、4周、6周的血清TGF-β1、TNF-α、IL-1β及MMP-12水平均高于对照组，两组患者之间比较差异均有统计学意义(P<0.05)。结论 PET-CT在食管癌放疗靶区勾画中的应用价值较高，可有效降低放疗对患者造成的不良影响。
목적：탐토파특CT (PET-CT)재식관암방료파구구화중적응용개치。방법선취2013년1월지2014년1월수치적60례식관암환자위연구대상，근거기방료파구구화방식적불동분위대조조(이CT진행정위급구화방료파구)30례화관찰조(이PET-CT진행정위급구화방료파구)30례，비교량조환자방사성폐손상발생솔급방사치료전화방사치료후1주、2주、4주、6주적혈청전화생장인자-β1(TGF-β1)、종류배사인자α(TNF-α)、백개소1β(IL-1β)급기질금속단백매12(MMP-12)수평。결과관찰조중불동부위병조자적방사성폐손상발생솔균저우대조조，방사치료후1주、2주、4주、6주적혈청TGF-β1、TNF-α、IL-1β급MMP-12수평균고우대조조，량조환자지간비교차이균유통계학의의(P<0.05)。결론 PET-CT재식관암방료파구구화중적응용개치교고，가유효강저방료대환자조성적불량영향。
Objective To study and observe the application value of Positron Emission Tomography-Com-puted Tomography (PET-CT) in the target delineation of radiotherapy of esophageal cancer. Methods Sixty pa-tients with esophageal cancer from January 2013 to January 2014 were selected as research objects, and they were di-vided into control group (CT group, 30 cases) and observation group (PET-CT group, 30 cases) according to differ-ent target delineation methods of radiotherapy. Then the radiation-induced lung injury rates, serum transforming growth factor-β1 (TGF-β1), tumor necrosis factorα(TNF-α), interleukin 1β(IL-1β), and matrix metalloproteinase 12 (MMP-12) before radiotherapy and 1, 2, 4, 6 weeks after radiotherapy of two groups were analyzed and com-pared, respectively. Results The radiation-induced lung injury rates of observation group with different parts of le-sions were lower than those of control group. Serum TGF-β1, TNF-α, IL-1βand MMP-12 1, 2, 4 and 6 weeks after radiotherapy were all higher than those of control group. The differences were all statistically significant (P<0.05). Conclusion The application value of PET-CT in the target delineation of radiotherapy of esophageal cancer is high, and it can effectively decrease the bad influence of radiotherapy for the patients.