CAJ | 학술논문

目的：探讨他克莫司软膏联合窄谱中波紫外线治疗白癜风的临床效果及其影响因素。方法172例白癜风患者随机分为观察组与对照组各86例，观察组给予他克莫司软膏联合窄谱中波紫外线治疗，对照组仅给予窄谱中波紫外线照射治疗，对比两组患者的临床效果。根据治疗效果，分析性别、年龄、病程、病变类型、皮损位置等因素对观察组患者疗效的影响。结果观察组有效率为76.7%(66/86)，显著高于对照组的52.3%(45/86)(P<0.01)；不同年龄、皮损部位、病程以及病变类型患者有效率比较差异均有统计学意义(P<0.05或P<0.01)，而不同性别患者有效率比较差异无统计学意义(P>0.05)。结论他克莫司软膏联合窄谱中波紫外线照射能够快速、有效的恢复白癜风患者患处肤色、缩小皮损面积，但患者年龄、病程、皮损位置、病变类型等因素对疗效影响较大。
목적：탐토타극막사연고연합착보중파자외선치료백전풍적림상효과급기영향인소。방법172례백전풍환자수궤분위관찰조여대조조각86례，관찰조급여타극막사연고연합착보중파자외선치료，대조조부급여착보중파자외선조사치료，대비량조환자적림상효과。근거치료효과，분석성별、년령、병정、병변류형、피손위치등인소대관찰조환자료효적영향。결과관찰조유효솔위76.7%(66/86)，현저고우대조조적52.3%(45/86)(P<0.01)；불동년령、피손부위、병정이급병변류형환자유효솔비교차이균유통계학의의(P<0.05혹P<0.01)，이불동성별환자유효솔비교차이무통계학의의(P>0.05)。결론타극막사연고연합착보중파자외선조사능구쾌속、유효적회복백전풍환자환처부색、축소피손면적，단환자년령、병정、피손위치、병변류형등인소대료효영향교대。
Objective To discuss the clinical effects and influence factors of tacrolimus combined with (NB-UVB) in patients with vitiligo. Methods A total of 172 patients with vitiligo were randomly divided into the ob-servation group (n=86) and the control group (n=86). The observation group were treated with tacrolimus combined with NB-UVB, while the control group were treated with NB-UVB only. Clinical effects were contrasted between the two groups. Then gender, age, course of disease, pathological type, vitiligo patches were analyzed according to the clinical effects to discuss the influence to the clinical effects. Results The effective rate of the observation group was 76.7%(66/86), significantly higher than 52.3%(45/86) in the control group (P<0.01). There were statistically significant differences in age, vitiligo patches, course of disease and pathological type in effective rates (P<0.05 or P<0.01), but there was no statistically significant difference in patients' gender (P>0.05). Conclusion Tacrolimus ointment com-bined with NB-UVB can rapidly, effectively recover skin color and shrink lesion area in patient's with vitiligo, but pa-tient's age, course of disease, lesion location, pathological type and other factors would influence the curative effect to a large extent.