CAJ | 학술논문

目的：观察泮托拉唑联合格拉司琼+甲氧氯普安+地塞米松方案预防化疗致胃肠道反应的临床疗效。方法86例恶性肿瘤化疗患者随机分为观察组43例和对照组43例，观察组应用泮托拉唑联合格拉司琼+甲氧氯普安+地塞米松治疗，对照组应用格拉司琼+甲氧氯普安+地塞米松治疗，比较两组的临床疗效与药物不良反应。结果观察组在预防恶心、呕吐、上腹部不适等方面疗效明显优于对照组，差异有统计学意义(P<0.05)；两组不良反应(头痛、头晕、乏力、腹泻、便秘、口干、失眠)发生率比较差异无统计学意义(P>0.05)。结论泮托拉唑联合格拉司琼+甲氧氯普安+地塞米松方案预防化疗药物所致胃肠道反应疗效较好，不良反应轻微，值得在临床上推广应用。
목적：관찰반탁랍서연합격랍사경+갑양록보안+지새미송방안예방화료치위장도반응적림상료효。방법86례악성종류화료환자수궤분위관찰조43례화대조조43례，관찰조응용반탁랍서연합격랍사경+갑양록보안+지새미송치료，대조조응용격랍사경+갑양록보안+지새미송치료，비교량조적림상료효여약물불량반응。결과관찰조재예방악심、구토、상복부불괄등방면료효명현우우대조조，차이유통계학의의(P<0.05)；량조불량반응(두통、두훈、핍력、복사、편비、구간、실면)발생솔비교차이무통계학의의(P>0.05)。결론반탁랍서연합격랍사경+갑양록보안+지새미송방안예방화료약물소치위장도반응료효교호，불량반응경미，치득재림상상추엄응용。
Objective To observe the clinical effect of pantoprazole combined with granisetron+metoclo pramide+dexamethasone in prevention of gastrointestinal reaction induced by chemotherapy. Methods A total of 86 malignant tumor chemotherapy patients were randomly divided into observation group with 43 cases and control group with 43 cases. The observation group received pantoprazole combined with metoclopramide+granis etron+dexamethasone for treatment, and the control group received metoclopramide+granisetron+dexamethasone. The clinical effects and adverse drug reactions were compared between the two groups. Results The observation group had much better effects in preventing nausea, emesis, and epigastric discomfort than the control group, and the difference had statistical significance (P<0.05). The incidences of adverse reactions (headache, dizziness, fatigue, diarrhea, constipation, dry mouth, insomnia) had no statistically significant difference between the two groups (P>0.05). Conclusion Scheme of pantoprazole combined with granisetron+metoclopramide+dexameth asone has good curative effect and slight adverse reactions in prevention of gastrointestinal reaction induced by chemotherapy, and it is worth promotion and application in clinic.