CAJ | 학술논문

鸟氨酸脱羧酶(Ornithine decarboxylase，ODC)是调控细胞内多胺生物合成的限速酶，参与胚胎发育、细胞周期、细胞增殖分化等重要的生理过程，同时也是肿瘤细胞的快速增殖所必须，是目前研究较多的抗肿瘤治疗的潜在分子靶点之一。本文简要综述ODC与女性常见恶性肿瘤关系的研究进展。
조안산탈최매(Ornithine decarboxylase，ODC)시조공세포내다알생물합성적한속매，삼여배태발육、세포주기、세포증식분화등중요적생리과정，동시야시종류세포적쾌속증식소필수，시목전연구교다적항종류치료적잠재분자파점지일。본문간요종술ODC여녀성상견악성종류관계적연구진전。
Ornithine decarboxylase (ODC) is the first rate-limiting enzyme in regulating intracellular poly-amine biosynthesis and is involved in many important physiological functions including embryonic development, cell cycle, cell proliferation and differentiation. In the same time, ODC is also needed by tumor cells for their rapid prolif-eration. Currently, it has been regarded as a potential molecular target for anti-tumor therapy. This article briefly re-views the research progress in the relationship between ODC and several common female malignant tumors.