海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2015年
2期
266-268
,共3页
车爱文%陈淑苹%谭旭东%李家梁%马红梅
車愛文%陳淑蘋%譚旭東%李傢樑%馬紅梅
차애문%진숙평%담욱동%리가량%마홍매
CIP2A%宫颈肿瘤%免疫组化
CIP2A%宮頸腫瘤%免疫組化
CIP2A%궁경종류%면역조화
CIP2A%Cervical cancer%Immunhistochemistry
目的:探讨CIP2A在宫颈癌(Cervical cancer)、宫颈上皮内瘤变(Cervical intraepithelial,CIN)及正常宫颈组织中的表达及其临床意义。方法应用免疫组化S-P法检测50例宫颈鳞状细胞癌、34例CINⅠ、40例CINⅡ、45例CINⅢ及12例正常宫颈组织中CIP2A蛋白的表达。结果 CIP2A蛋白在宫颈癌中的表达明显高于宫颈上皮内瘤变及正常宫颈组织,且与宫颈癌淋巴结转移及临床分期有关,差异均有统计学意义(P<0.05)。结论 CIP2A在宫颈鳞状细胞癌中过表达,且与宫颈癌的恶性临床病理特征密切相关,为将来发展以CIP2A为靶分子的宫颈癌临床诊断和新的治疗策略提供了新的思路。
目的:探討CIP2A在宮頸癌(Cervical cancer)、宮頸上皮內瘤變(Cervical intraepithelial,CIN)及正常宮頸組織中的錶達及其臨床意義。方法應用免疫組化S-P法檢測50例宮頸鱗狀細胞癌、34例CINⅠ、40例CINⅡ、45例CINⅢ及12例正常宮頸組織中CIP2A蛋白的錶達。結果 CIP2A蛋白在宮頸癌中的錶達明顯高于宮頸上皮內瘤變及正常宮頸組織,且與宮頸癌淋巴結轉移及臨床分期有關,差異均有統計學意義(P<0.05)。結論 CIP2A在宮頸鱗狀細胞癌中過錶達,且與宮頸癌的噁性臨床病理特徵密切相關,為將來髮展以CIP2A為靶分子的宮頸癌臨床診斷和新的治療策略提供瞭新的思路。
목적:탐토CIP2A재궁경암(Cervical cancer)、궁경상피내류변(Cervical intraepithelial,CIN)급정상궁경조직중적표체급기림상의의。방법응용면역조화S-P법검측50례궁경린상세포암、34례CINⅠ、40례CINⅡ、45례CINⅢ급12례정상궁경조직중CIP2A단백적표체。결과 CIP2A단백재궁경암중적표체명현고우궁경상피내류변급정상궁경조직,차여궁경암림파결전이급림상분기유관,차이균유통계학의의(P<0.05)。결론 CIP2A재궁경린상세포암중과표체,차여궁경암적악성림상병리특정밀절상관,위장래발전이CIP2A위파분자적궁경암림상진단화신적치료책략제공료신적사로。
Objective To explore the expression and clinical significance of CIP2A protein in cervical can-cer, cervical intraepithelial and normal cervical tissue. Methods The expressions of CIP2A in 50 cases of cervical cancer, 34 cases of CINⅠ, 40 cases of CINⅡ, 45 cases of CINⅢand 12 cases of normal tissues were assessed by immunohistochemical S-P method. Results The expression of CIP2A protein in cancer tissues was significantly higher than those in CIN tissues and normal tissues (P<0.05) and closely correlated with TNM stage and metastasis. Conclusion CIP2A is overexpressed in cervical squamous cell cancer and closely correlated with the malignant clinicopathologic feature of cervical cancer. Therefore, CIP2A, as a target molecule, may provide a new thought for the clinical diagnosis and treatment strategy of cervical cancer.