中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
2期
7-9
,共3页
氨咖黄敏片%对乙酰氨基酚%溶出度%高效液相色谱法
氨咖黃敏片%對乙酰氨基酚%溶齣度%高效液相色譜法
안가황민편%대을선안기분%용출도%고효액상색보법
Paracetamol,caffein,artificial cow-bezoar and chlophenamine maleate tablets%Acetaminophen%Dissolution%High performance liquid chromatography
目的：建立氨咖黄敏片中对乙酰氨基酚的溶出度测定方法。方法采用桨法，以900 ml水作为溶出介质，转速为50 r/min，以高效液相色谱法测定。采用C18柱，以乙腈-水-三乙胺(15：85：1.5)(用磷酸调pH至3.0)为流动相，检测波长为243 nm。结果对乙酰氨基酚在0.0625~0.3750 mg/ml的范围内呈现良好的线性关系(r=0.9995)，平均回收率为100.1%，R SD值为0.39%(n=9)。样品溶出均一性好，在30 min时6片中对乙酰氨基酚的溶出度均达90%以上。结论本方法快速、简便、结果准确，可作为该制剂中对乙酰氨基酚的溶出度测定方法。
目的：建立氨咖黃敏片中對乙酰氨基酚的溶齣度測定方法。方法採用槳法，以900 ml水作為溶齣介質，轉速為50 r/min，以高效液相色譜法測定。採用C18柱，以乙腈-水-三乙胺(15：85：1.5)(用燐痠調pH至3.0)為流動相，檢測波長為243 nm。結果對乙酰氨基酚在0.0625~0.3750 mg/ml的範圍內呈現良好的線性關繫(r=0.9995)，平均迴收率為100.1%，R SD值為0.39%(n=9)。樣品溶齣均一性好，在30 min時6片中對乙酰氨基酚的溶齣度均達90%以上。結論本方法快速、簡便、結果準確，可作為該製劑中對乙酰氨基酚的溶齣度測定方法。
목적：건립안가황민편중대을선안기분적용출도측정방법。방법채용장법，이900 ml수작위용출개질，전속위50 r/min，이고효액상색보법측정。채용C18주，이을정-수-삼을알(15：85：1.5)(용린산조pH지3.0)위류동상，검측파장위243 nm。결과대을선안기분재0.0625~0.3750 mg/ml적범위내정현량호적선성관계(r=0.9995)，평균회수솔위100.1%，R SD치위0.39%(n=9)。양품용출균일성호，재30 min시6편중대을선안기분적용출도균체90%이상。결론본방법쾌속、간편、결과준학，가작위해제제중대을선안기분적용출도측정방법。
Objective To establish a dissolution determination method of acetaminophen from paracetamol,caffein,artifi-cial cow-bezoar and chlophenamine maleate tablets. Methods The paddle method was used and with 900 ml water as dissolution medium at the rotation speed of 50 r/min,the acetaminophen was determined by HPLC.The C18 column was used with the mobile phase of acetonitrile-water-triethylamine(15:85:1.5)(pH was adjusted to 3.0 by phosphoric acid)at the detection wavelength of 243 nm. Results The linear range of acetaminophen was 0.0625-0.3750 mg/ml (r=0.9995), the average recovery (n=9)was 100.1%(RSD=0.39%).The sample was dissolved uniformly,and the solubilities of the 6 tablets were above 90%. Conclusion The method is rapid,simple and accurate for dissolution determination of ac-etaminophen from paracetamol,caffein,artificial cow-bezoar and chlophenamine maleate tablets.
