CAJ | 학술논문

目的：研究小鼠最大灌胃量及其对小鼠心电图和心肌组织的影响。方法采用不同体重的小鼠灌胃后测定胃最大容量；以PEG6000制备不同黏度的溶液，以不同灌胃量灌胃后，记录小鼠心电图T波变化，制备小鼠心肌组织病理切片，光镜观察。结果在一定的体重范围内，小鼠体重与其灌胃量间存在一定的线性关系。与空白组比较，20 g/100 ml和40 g/100 ml两种黏度的PEG6000灌胃后小鼠心电图T波变化没有统计学意义(P>0.05)，小鼠心肌组织切片未见异常。结论可按线性关系推算小鼠的最大灌胃量；以最大灌胃量灌胃，在一定黏度范围内，小鼠的心电图及心肌组织未受影响。
목적：연구소서최대관위량급기대소서심전도화심기조직적영향。방법채용불동체중적소서관위후측정위최대용량；이PEG6000제비불동점도적용액，이불동관위량관위후，기록소서심전도T파변화，제비소서심기조직병리절편，광경관찰。결과재일정적체중범위내，소서체중여기관위량간존재일정적선성관계。여공백조비교，20 g/100 ml화40 g/100 ml량충점도적PEG6000관위후소서심전도T파변화몰유통계학의의(P>0.05)，소서심기조직절편미견이상。결론가안선성관계추산소서적최대관위량；이최대관위량관위，재일정점도범위내，소서적심전도급심기조직미수영향。
Objective To study the maximum tolerant dosage of mice by gastric perfusion and examine the influence of the electrocardiogram and myocardial tissue. Methods The maximum capacity was determined by using different body weight of mice after gastric perfusion.PEG6000 solution with different viscosity was prepared,and the T wave changes in ECG were recorded after administrating various dosages by gastric perfusion.The pathological sections of myocardial tissue was prepared and observed by using light and electron microscopy. Results In a certain weight range,linear rela-tionship exists between the weight of mice and the gastric volume.Compared with the blank group,T wave changes of ECG in mice after gastric perfusion with 20 g/ml and 40 g/ml PEG6000 solutions had no statistical difference (P>0.05), and myocardial tissue sections in mice showed no abnormalities. Conclusion Maximum intragastric volume of mice can be calculated according to the linear relationship;It has no effect of ECG and myocardial tissue with the greatest amount of intragastic gavage in a certain solution viscosity range.