CAJ | 학술논문

目的：探讨奥氮平联合氨磺必利治疗难治性精神分裂症的临床效果。方法选择本院2013年6月~2014年6月收治的难治性精神分裂症患者60例，将其平均分为观察组和对照组，对照组单用奥氮平进行治疗，观察组给予奥氮平联合氨磺必利治疗，比较两组的临床疗效、治疗前后生活质量评分、抑郁及焦虑评分、不良反应发生情况。结果观察组治疗总有效率为93.33%，高于对照组的73.33%，差异有统计学意义(P<0.05)。治疗后两组生活质量评分均较治疗前提高，差异有统计学意义(P<0.05)；且观察组提高程度明显优于对照组，差异有统计学意义(P<0.05)。治疗后两组抑郁及焦虑评分均较治疗前降低，差异有统计学意义(P<0.05)；且观察组降低幅度明显优于对照组，差异有统计学意义(P<0.05)。观察组不良反应发生率为3.33%，低于对照组的20.00%，差异有统计学意义(χ2=4.0431，P<0.05)。结论奥氮平联合氨磺必利治疗难治性精神分裂症效果显著，可有效改善患者的生活质量，减缓患者的抑郁及焦虑情绪，降低药物不良反应发生率，值得临床推广应用。
목적：탐토오담평연합안광필리치료난치성정신분렬증적림상효과。방법선택본원2013년6월~2014년6월수치적난치성정신분렬증환자60례，장기평균분위관찰조화대조조，대조조단용오담평진행치료，관찰조급여오담평연합안광필리치료，비교량조적림상료효、치료전후생활질량평분、억욱급초필평분、불량반응발생정황。결과관찰조치료총유효솔위93.33%，고우대조조적73.33%，차이유통계학의의(P<0.05)。치료후량조생활질량평분균교치료전제고，차이유통계학의의(P<0.05)；차관찰조제고정도명현우우대조조，차이유통계학의의(P<0.05)。치료후량조억욱급초필평분균교치료전강저，차이유통계학의의(P<0.05)；차관찰조강저폭도명현우우대조조，차이유통계학의의(P<0.05)。관찰조불량반응발생솔위3.33%，저우대조조적20.00%，차이유통계학의의(χ2=4.0431，P<0.05)。결론오담평연합안광필리치료난치성정신분렬증효과현저，가유효개선환자적생활질량，감완환자적억욱급초필정서，강저약물불량반응발생솔，치득림상추엄응용。
Objective To investigate the clinical effect of olanzapine combined with amisulpride in treatment of refrac-tory schizophrenia. Methods 60 patients with refractory schizophrenia accepted in our hospital from June 2013 to June 2014 were selected,and were randomly divided into observation group and control group,30 cases in each group,patients in observation group were treated with olanzapine combined with amisulpride,but patients in control group were treated with olanzapine only.The clinical effect,improvement of the life quality before and after treatment and the improvement of depression score and anxiety score,adverse reaction was observed. Results After treatment,the total effective rate of observation group was 93.33%,higher than 73.33%of the control group,the difference was significant (P<0.05).The life quality score of the two groups was increased compared with before treatment (P<0.05),and the observation group was higher than that of the control group (P<0.05).The depression and anxiety score of the two groups was decreased com-pared with before treatment (P<0.05),and the observation group was lower than that of the control group (P<0.05).The incidence of adverse reaction in the observation group was 3.33%,lower than 20.00% in the control group,the difference was significant (P<0.05). Conclusion The effect of olanzapine combined with amisulpride in treatment of refractory schizophrenia is significant,which can effectively improve the life quality of patients,relieve the depression and anxiety, decrease the incidence of adverse reaction and is worthy of promotion in clinic.