CAJ | 학술논문

目的：观察短期大剂量爱普列特联合坦络新治疗前列腺增生症并尿潴留的疗效及安全性。方法将2006年6月~2014年6月在本院就诊的50例良性前列腺增生症并尿潴留患者随机分为观察组(30例)和对照组(20例)。观察组给予爱普列特10 mg，口服，2次/d；坦络新0.4 mg，口服，每晚1次。对照组给予爱普列特5 mg，口服，2次/d；坦络新0.2 mg，口服，每晚1次。治疗4周后，观察两组患者尿管拔除率及拔除时间，两组恢复自主排尿患者最大尿流率、膀胱残余尿量，同时观察两组患者治疗过程中的不良反应发生情况。结果观察组27例拔除尿管，尿管拔除率为90.00%；对照组11例拔除尿管，尿管拔除率为55.00%；观察组尿管拔除率显著高于对照组(孕<0.05)。观察组尿管拔除时间显著短于对照组(孕<0.05)。观察组27例恢复自主排尿患者平均最大尿流率为(14±4)ml/s，平均膀胱残余尿量为(25±6)ml；对照组11例恢复自主排尿患者平均最大尿流率为(10±3) ml/s，平均膀胱残余尿量为(40±8) ml；观察组平均最大尿流率高于对照组(孕<0.05)，平均膀胱残余尿量低于对照组(孕<0.05)。50例患者治疗过程中无严重不良事件而停止服药或减量服药。结论短期大剂量爱普列特联合坦络新治疗前列腺增生症并尿潴留安全，有效，可避免或推迟手术及尿流改道。
목적：관찰단기대제량애보렬특연합탄락신치료전렬선증생증병뇨저류적료효급안전성。방법장2006년6월~2014년6월재본원취진적50례량성전렬선증생증병뇨저류환자수궤분위관찰조(30례)화대조조(20례)。관찰조급여애보렬특10 mg，구복，2차/d；탄락신0.4 mg，구복，매만1차。대조조급여애보렬특5 mg，구복，2차/d；탄락신0.2 mg，구복，매만1차。치료4주후，관찰량조환자뇨관발제솔급발제시간，량조회복자주배뇨환자최대뇨류솔、방광잔여뇨량，동시관찰량조환자치료과정중적불량반응발생정황。결과관찰조27례발제뇨관，뇨관발제솔위90.00%；대조조11례발제뇨관，뇨관발제솔위55.00%；관찰조뇨관발제솔현저고우대조조(잉<0.05)。관찰조뇨관발제시간현저단우대조조(잉<0.05)。관찰조27례회복자주배뇨환자평균최대뇨류솔위(14±4)ml/s，평균방광잔여뇨량위(25±6)ml；대조조11례회복자주배뇨환자평균최대뇨류솔위(10±3) ml/s，평균방광잔여뇨량위(40±8) ml；관찰조평균최대뇨류솔고우대조조(잉<0.05)，평균방광잔여뇨량저우대조조(잉<0.05)。50례환자치료과정중무엄중불량사건이정지복약혹감량복약。결론단기대제량애보렬특연합탄락신치료전렬선증생증병뇨저류안전，유효，가피면혹추지수술급뇨류개도。
Objective To evaluate the effect of short-term large doses epristeride tablets combined with tamsulosin hy-drochloride sustained release tablets in treatment of benign prostatic hyperplasia and urinary retention. Methods 50 cases of patients with benign prostatic enlargement and urinary retention were randomly divided into observation group (30 patients) and control group (20 patients).The observation group were taken with epristeride tablets every time 10 mg,two times a day,and taken with tamsulosin hydrochloride sustained release tablets every time 0.4 mg,once a day at night.The control group were taken with epristeride tablets every time 5 mg,two times a day,and taken with tamsulosin hydrochloride sustained release tablets 0.2 mg every time,once a day at night.After four weeks treatment,the ratio and time of removing catheter,and the maximal urinary flow rate and postvoid residual urine of patients with the automatic micturition ability recovered in the two groups were evaluated.Meanwhile,the adverse effect in the two groups were ob-served and recorded. Results The catheter removal rate of observation group was 90.00% (27/30),higher than 55.00%(11/20) of the control group,the difference was significant (P<0.05).The catheter removing time of observation group was shorter than that of control group,the difference was significant (P<0.05).The average maximal urinary flow rate of the 27 patients with the automatic micturition ability recovered in the observation group was (14±4) ml/s,and the average postvoid residual urine was (25±6) ml;While the average maximal urinary flow rate and the average postvoid residual urine of the 11 patients with automatic micturition recovered in the control group was (10±3) ml/s and (40±8) ml re-spectively.The average maximal urinary flow rate in the observation group was higher than that in the control group (P<0.05),and the average postvoid residual urine in the observation group was lower than that in the control group (P<0.05).No serious side effect was observed that caused drug withdraw and reduction during the drug treatment among the 50 patients. Conclusion Short-term large doses epristeride tablets combined with tamsulosin hydrochloride sustained release tablets in treatment of benign prostatic enlargement and urinary retention is effective and safe,can avoid post-pone surgery and urethra rechanneling.