中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
2期
106-108,111
,共4页
来曲唑%地屈孕酮%多囊卵巢综合征%不孕
來麯唑%地屈孕酮%多囊卵巢綜閤徵%不孕
래곡서%지굴잉동%다낭란소종합정%불잉
Letrozole%Dydrogesterone%Polycystic ovary syndrome%Infertility
目的：探讨来曲唑联合地屈孕酮治疗多囊卵巢综合征不孕的临床效果。方法选择2012年1月~2014年6月来本院就诊的多囊卵巢综合征不孕妇女295例，随机分为3组，观察组101例采用来曲唑联合地屈孕酮治疗，对照组A 96例采用克罗米芬治疗，对照组B 98例采用来曲唑治疗。观察3组的排卵及受孕情况。结果观察组及对照组B成熟卵泡发育率、单个成熟卵泡发育率、排卵率、HCG注射日子宫内膜厚度均高于对照组A，差异有统计学意义(P<0.05)；观察组妊娠率显著高于对照组A及对照组B，差异有统计学意义(P<0.05)。观察组及对照组B的卵巢过度刺激综合征(OHSS)、黄素化未破裂卵泡综合征(LUFS)发生率均低于对照组A，差异有统计学意义(P<0.05)。结论来曲唑联合地屈孕酮对多囊卵巢综合征不孕妇女促排卵治疗安全有效，妊娠率高，值得临床推广应用。
目的：探討來麯唑聯閤地屈孕酮治療多囊卵巢綜閤徵不孕的臨床效果。方法選擇2012年1月~2014年6月來本院就診的多囊卵巢綜閤徵不孕婦女295例，隨機分為3組，觀察組101例採用來麯唑聯閤地屈孕酮治療，對照組A 96例採用剋囉米芬治療，對照組B 98例採用來麯唑治療。觀察3組的排卵及受孕情況。結果觀察組及對照組B成熟卵泡髮育率、單箇成熟卵泡髮育率、排卵率、HCG註射日子宮內膜厚度均高于對照組A，差異有統計學意義(P<0.05)；觀察組妊娠率顯著高于對照組A及對照組B，差異有統計學意義(P<0.05)。觀察組及對照組B的卵巢過度刺激綜閤徵(OHSS)、黃素化未破裂卵泡綜閤徵(LUFS)髮生率均低于對照組A，差異有統計學意義(P<0.05)。結論來麯唑聯閤地屈孕酮對多囊卵巢綜閤徵不孕婦女促排卵治療安全有效，妊娠率高，值得臨床推廣應用。
목적：탐토래곡서연합지굴잉동치료다낭란소종합정불잉적림상효과。방법선택2012년1월~2014년6월래본원취진적다낭란소종합정불잉부녀295례，수궤분위3조，관찰조101례채용래곡서연합지굴잉동치료，대조조A 96례채용극라미분치료，대조조B 98례채용래곡서치료。관찰3조적배란급수잉정황。결과관찰조급대조조B성숙란포발육솔、단개성숙란포발육솔、배란솔、HCG주사일자궁내막후도균고우대조조A，차이유통계학의의(P<0.05)；관찰조임신솔현저고우대조조A급대조조B，차이유통계학의의(P<0.05)。관찰조급대조조B적란소과도자격종합정(OHSS)、황소화미파렬란포종합정(LUFS)발생솔균저우대조조A，차이유통계학의의(P<0.05)。결론래곡서연합지굴잉동대다낭란소종합정불잉부녀촉배란치료안전유효，임신솔고，치득림상추엄응용。
Objectives To explore the clinical effect of letrozole combined with dydrogesterone in the treatment of in-fertility in women with polycystic ovary syndromen (PCOS). Methods 295 infertility patients with PCOS treated in our hospital from January 2012 to June 2014 were selected,and were divided into 3 groups randomly,the observation group (101 cases) were taken with letrozole and dydrogesterone,control group A (96 cases) were only taken with clomiphene, control group B (98 cases) were only taken with letrozole.The effect of ovulation induction and clinical pregnancy rate of the 3 groups was compared and analyzed. Results The observation group and control group B had better effect than that of control group A in mature follicle growth rate,a single mature follicle growth rate,ovulation rate and endometrial thickness at HCG injection day (P<0.05);the clinical pregnancy rate in observation group was higher than that in control group A and control group B (P<0.05).The incidence of ovarian hyperstimulation syndrome (OHSS) and luteinized un-ruptured follicle syndrome (LUFS) in observation group and control group B was lower than that in control group A,the difference was significant (P<0.05). Conclusion Letrozole combined with dydrogesterone has good effect of ovulation induction and clinical pregnancy rate in infertility women with PCOS,and is effective and conducive to the development of endometrium for infertile women with PCOS.
