中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
2期
103-105
,共3页
抗生素相关性腹泻%枯草杆菌二联活菌肠溶胶囊%地衣芽胞杆菌活菌胶囊
抗生素相關性腹瀉%枯草桿菌二聯活菌腸溶膠囊%地衣芽胞桿菌活菌膠囊
항생소상관성복사%고초간균이련활균장용효낭%지의아포간균활균효낭
Antibiotic associated diarrhea%Bacillus subtilis two (Live) enteric-coated capsules%Bacillus licheniformis capsule
目的：探讨枯草杆菌二联活菌肠溶胶囊联合地衣芽胞杆菌活菌胶囊对老年抗生素相关性腹泻的临床疗效。方法收集2013年2月~2014年2月本院老年抗生素相关性腹泻患者120例，根据随机数字表法分为枯草杆菌二联活菌肠溶胶囊组、地衣芽胞杆菌活菌胶囊组、枯草杆菌二联活菌肠溶胶囊和地衣芽胞杆菌活菌胶囊联合组各40例。比较3组的治疗效果。结果联合组1个月内的腹泻治愈率高于枯草杆菌二联活菌肠溶胶囊组及地衣芽胞杆菌活菌胶囊组，差异有统计学意义(χ2=8.26，P=0.02)。联合组未愈患者1个月内的腹泻次数明显低于枯草杆菌二联活菌肠溶胶囊组及地衣芽胞杆菌活菌胶囊组，差异有统计学意义(F=91.03，P=0.00)。结论枯草杆菌二联活菌肠溶胶囊以及地衣芽胞杆菌活菌胶囊均为益生菌类药物，对治疗老年人抗生素相关性腹泻有一定的疗效，但是枯草杆菌二联活菌肠溶胶囊联合地衣芽胞杆菌活菌胶囊对老年抗生素相关性腹泻的疗效更显著，对于临床治疗有一定的协助作用。
目的：探討枯草桿菌二聯活菌腸溶膠囊聯閤地衣芽胞桿菌活菌膠囊對老年抗生素相關性腹瀉的臨床療效。方法收集2013年2月~2014年2月本院老年抗生素相關性腹瀉患者120例，根據隨機數字錶法分為枯草桿菌二聯活菌腸溶膠囊組、地衣芽胞桿菌活菌膠囊組、枯草桿菌二聯活菌腸溶膠囊和地衣芽胞桿菌活菌膠囊聯閤組各40例。比較3組的治療效果。結果聯閤組1箇月內的腹瀉治愈率高于枯草桿菌二聯活菌腸溶膠囊組及地衣芽胞桿菌活菌膠囊組，差異有統計學意義(χ2=8.26，P=0.02)。聯閤組未愈患者1箇月內的腹瀉次數明顯低于枯草桿菌二聯活菌腸溶膠囊組及地衣芽胞桿菌活菌膠囊組，差異有統計學意義(F=91.03，P=0.00)。結論枯草桿菌二聯活菌腸溶膠囊以及地衣芽胞桿菌活菌膠囊均為益生菌類藥物，對治療老年人抗生素相關性腹瀉有一定的療效，但是枯草桿菌二聯活菌腸溶膠囊聯閤地衣芽胞桿菌活菌膠囊對老年抗生素相關性腹瀉的療效更顯著，對于臨床治療有一定的協助作用。
목적：탐토고초간균이련활균장용효낭연합지의아포간균활균효낭대노년항생소상관성복사적림상료효。방법수집2013년2월~2014년2월본원노년항생소상관성복사환자120례，근거수궤수자표법분위고초간균이련활균장용효낭조、지의아포간균활균효낭조、고초간균이련활균장용효낭화지의아포간균활균효낭연합조각40례。비교3조적치료효과。결과연합조1개월내적복사치유솔고우고초간균이련활균장용효낭조급지의아포간균활균효낭조，차이유통계학의의(χ2=8.26，P=0.02)。연합조미유환자1개월내적복사차수명현저우고초간균이련활균장용효낭조급지의아포간균활균효낭조，차이유통계학의의(F=91.03，P=0.00)。결론고초간균이련활균장용효낭이급지의아포간균활균효낭균위익생균류약물，대치료노년인항생소상관성복사유일정적료효，단시고초간균이련활균장용효낭연합지의아포간균활균효낭대노년항생소상관성복사적료효경현저，대우림상치료유일정적협조작용。
Objective To explore the clinical effect of Bacillus subtilis two (Live) enteric-coated capsules combined with Bacillus licheniformis capsule in the treatment of antibiotic associated diarrhea. Methods 120 patients with an-tibiotic associated diarrhea in our hospital from February 2013 to February 2014 were selected,and were divided into three groups based on random number table,Bacillus subtilis two (Live) enteric-coated capsules group,Bacillus licheni-formis capsule group,and joint application of Bacillus subtilis two (Live) enteric-coated capsules and Bacillus licheni-formis capsule group.The therapeutic effects among three groups were compared. Results The cure rate of joint applica-tion of Bacillus subtilis two (Live) enteric-coated capsules and Bacillus licheniformis capsule group was higher than that of Bacillus subtilis two (Live) enteric-coated capsules group and Bacillus licheniformis capsule group,the differ-ence was significant (χ2=8.26,P=0.02).The number of diarrhea in healed patients of joint application of Bacillus subtilis two (Live) enteric-coated capsules and Bacillus licheniformis capsule group was less than that of Bacillus subtilis two (Live) enteric-coated capsules group and Bacillus licheniformis capsule group,the difference was significant (F=91.03, P=0.00). Conclusion Both Bacillus subtilis two (Live) enteric-coated capsules and Bacillus licheniformis capsule are classified into probiotics,and have some effect on treating senile associated diarrhea caused by antibiotics.Joint applica-tion of the two drugs displays remarkable effect on treating antibiotic associated diarrhea,and plays a certain assistant role in clinical treatment.
