中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
2期
93-95
,共3页
廖婉婷%邓列华%李克俭%徐瑾%李诗娜%胡云峰%刘赛君
廖婉婷%鄧列華%李剋儉%徐瑾%李詩娜%鬍雲峰%劉賽君
료완정%산렬화%리극검%서근%리시나%호운봉%류새군
股癣%伊曲康唑%联苯苄唑乳膏%联合治疗
股癬%伊麯康唑%聯苯芐唑乳膏%聯閤治療
고선%이곡강서%련분변서유고%연합치료
Tinea cruris%Itraconazole%Bifonazole cream%Combined treatment
目的：观察伊曲康唑胶囊联合联苯苄唑乳膏治疗股癣的临床效果。方法将2012年9月~2014年6月本院皮肤科门诊260例股癣患者随机分为治疗组和对照组各130例，治疗组口服伊曲康唑胶囊200 mg/次，1次/d，并联合外用联苯苄唑乳膏，1次/d，连用4周；对照组仅外用联苯苄唑乳膏，1次/d，连用4周。比较两组的临床疗效。结果用药1周后，治疗组总有效率为33.08%、真菌清除率为33.08%，对照组总有效率为27.69%、真菌清除率为27.69%；用药2周后，治疗组总有效率为62.31%、真菌清除率为62.31%，对照组总有效率为40.77%、真菌清除率为40.77%；用药4周后，治疗组总有效率为91.54%、真菌清除率为91.54%，对照组总有效率为58.46%、真菌清除率为58.46%；治疗2、4周后，治疗组总有效率及真菌清除率高于对照组，差异有统计学意义(P<0.05)。结论口服伊曲康唑胶囊加外用联苯苄唑乳膏联合治疗股癣4周疗效显著，且安全、无明显毒副作用。
目的：觀察伊麯康唑膠囊聯閤聯苯芐唑乳膏治療股癬的臨床效果。方法將2012年9月~2014年6月本院皮膚科門診260例股癬患者隨機分為治療組和對照組各130例，治療組口服伊麯康唑膠囊200 mg/次，1次/d，併聯閤外用聯苯芐唑乳膏，1次/d，連用4週；對照組僅外用聯苯芐唑乳膏，1次/d，連用4週。比較兩組的臨床療效。結果用藥1週後，治療組總有效率為33.08%、真菌清除率為33.08%，對照組總有效率為27.69%、真菌清除率為27.69%；用藥2週後，治療組總有效率為62.31%、真菌清除率為62.31%，對照組總有效率為40.77%、真菌清除率為40.77%；用藥4週後，治療組總有效率為91.54%、真菌清除率為91.54%，對照組總有效率為58.46%、真菌清除率為58.46%；治療2、4週後，治療組總有效率及真菌清除率高于對照組，差異有統計學意義(P<0.05)。結論口服伊麯康唑膠囊加外用聯苯芐唑乳膏聯閤治療股癬4週療效顯著，且安全、無明顯毒副作用。
목적：관찰이곡강서효낭연합련분변서유고치료고선적림상효과。방법장2012년9월~2014년6월본원피부과문진260례고선환자수궤분위치료조화대조조각130례，치료조구복이곡강서효낭200 mg/차，1차/d，병연합외용련분변서유고，1차/d，련용4주；대조조부외용련분변서유고，1차/d，련용4주。비교량조적림상료효。결과용약1주후，치료조총유효솔위33.08%、진균청제솔위33.08%，대조조총유효솔위27.69%、진균청제솔위27.69%；용약2주후，치료조총유효솔위62.31%、진균청제솔위62.31%，대조조총유효솔위40.77%、진균청제솔위40.77%；용약4주후，치료조총유효솔위91.54%、진균청제솔위91.54%，대조조총유효솔위58.46%、진균청제솔위58.46%；치료2、4주후，치료조총유효솔급진균청제솔고우대조조，차이유통계학의의(P<0.05)。결론구복이곡강서효낭가외용련분변서유고연합치료고선4주료효현저，차안전、무명현독부작용。
Objective To observe the clinical effect of itraconazole capsulue combined with bifonazole cream in the treatment of tinea cruris. Methods 260 patients with tinea cruris in the Department of Dermatology in our hospital from September 2012 to June 2014 were evenly divided into treatment group and control group in random.In treatment group,200 mg itraconazole capsulue was provided for oral administration each time,once per day,and bifonazole cream was selected for external application once per day for 4 consecutive weeks.In control group,only bifonazole cream for external application was used once per day for 4 continuous weeks.The clinical efficacy was observed. Results After one-week treatment,the total effective rate and fungal clearance rate was 33.08% in the treatment group,was 27.69% in the control group;After two-week treatment,the total effective rate and fungal clearance rate was 62.31% in the treat-ment group,was 40.77% in the control group.After 4 weeks treatment,the total effective rate and fungal clearance rate was 91.54% in the treatment group,was 58.46% in the control group.There was statistical difference about the total ef-fective rate and fungal clearance rate between the two groups after 2 and 4 weeks treatment (P<0.05). Conclusion Oral administration of itraconazole capsulue combined with external application of bifonazole cream in the treatment of tinea cruris for 4 weeks can obtain a remarkable effect at advantages of safety and non-toxic and side effects.
