CAJ | 학술논문

目的：探讨雾化吸入布地奈德联合沙丁胺醇对慢性阻塞性肺疾病(COPD)稳定期患者肺功能和生活质量的影响。方法将本院2011年8月~2012年5月门诊100例COPD患者随机分为对照组和实验组各50例，对照组给予氨茶碱治疗，实验组在对照组治疗的基础上加用雾化吸入布地奈德联合沙丁胺醇。测定两组治疗前及治疗6个月后肺功能(FEV1预计值以及FEV1/FVC值)及COPD评估测试(CAT)问卷的评分，6 min行走距离(6-MWD)。结果治疗后，两组FEV1预计值、FEV1/FVC均较治疗前下降，差异有统计学意义(P<0.05)；且实验组FEV1预计值、FEV1/FVC改善显著，与对照组比较，差异有统计学意义(P<0.05)。两组CAT评分均显著降低(P<0.05)，且实验组的总评分低于对照组，差异有统计学意义(P<0.05)。两组6-MWD较前均有明显改善(P<0.05)，且实验组6-MWD优于对照组，差异有统计学意义(P<0.05)。结论吸入布地奈德联合沙丁胺醇能改善COPD患者的临床症状及运动耐力，延缓肺功能下降速率。
목적：탐토무화흡입포지내덕연합사정알순대만성조새성폐질병(COPD)은정기환자폐공능화생활질량적영향。방법장본원2011년8월~2012년5월문진100례COPD환자수궤분위대조조화실험조각50례，대조조급여안다감치료，실험조재대조조치료적기출상가용무화흡입포지내덕연합사정알순。측정량조치료전급치료6개월후폐공능(FEV1예계치이급FEV1/FVC치)급COPD평고측시(CAT)문권적평분，6 min행주거리(6-MWD)。결과치료후，량조FEV1예계치、FEV1/FVC균교치료전하강，차이유통계학의의(P<0.05)；차실험조FEV1예계치、FEV1/FVC개선현저，여대조조비교，차이유통계학의의(P<0.05)。량조CAT평분균현저강저(P<0.05)，차실험조적총평분저우대조조，차이유통계학의의(P<0.05)。량조6-MWD교전균유명현개선(P<0.05)，차실험조6-MWD우우대조조，차이유통계학의의(P<0.05)。결론흡입포지내덕연합사정알순능개선COPD환자적림상증상급운동내력，연완폐공능하강속솔。
Objective To investigate the effect of aerosol inhalation of budesonide combined with salbutamol on the lung function and quality of life in patients with chronic obstructive pulmonary disease (COPD). Methods 100 patients with COPD were randomly divided into control group and experiment group,50 cases in each group,the control group were given with aminophylline,the experiment group were added with aerosol inhalation of budesonide and salbutamol on the basis of control group.The lung function (FEV1 and FEV1/FVC),COPD assessment test (CAT) and walking dis-tance of 6 minutes (6-MWD) was measured before and after 6 months treatment. Results After treatment,FEV1 and FEV1/FVC of the two groups was decreased compared with before treatment,the difference was significant (P<0.05);and the improvement of experiment group was better than that of control group,the difference was significant (P<0.05).The CAT score of two groups was decreased compared with before treatment,the difference was significant (P<0.05);and the score of experiment group was lower than that of control group,the difference was significant (P<0.05).The 6-MWD of two groups was improved compared with before treatment,the difference was significant (P<0.05);and the improvement of experiment group was better than that of control group,the difference was significant (P<0.05). Conclusion Inhalation of budesonide and salbutamol is able to improve the quality of life and slow down the decreasing rate of lung function of patients with COPD.