CAJ | 학술논문

目的：探讨血清同型半胱氨酸（Hcy）与踝肱指数（ABI）在评估糖尿病患者周围动脉病变（PAD）中的相关性。方法选择2011年8月至2012年6月厦门市第二医院收治的2型糖尿病患者204例，均测定血清Hcy及ABI，并根据Hcy 水平分为A 组（Hcy＜15μmol/L，167例）和B组（Hcy≥15μmol/L，37例）；根据ABI水平分为非 PAD 组（0.9＜ABI≤1.3，140例）、PAD组（ABI≤0.9，19例）和动脉硬化组（ABI>1.3，45例），比较不同组间Hcy和ABI水平的变化情况。结果动脉硬化组患者血清Hcy最高，PAD组次之，非PAD组血清Hcy最低，三组两两比较，差异均有统计学意义（P＜0.05）；B组患者异常ABI的比率明显高于A组，差异有统计学意义（P＜0.01）。结论血清Hcy与2型糖尿病PAD关系密切，有望成为糖尿病PAD的血清标志物。
목적：탐토혈청동형반광안산（Hcy）여과굉지수（ABI）재평고당뇨병환자주위동맥병변（PAD）중적상관성。방법선택2011년8월지2012년6월하문시제이의원수치적2형당뇨병환자204례，균측정혈청Hcy급ABI，병근거Hcy 수평분위A 조（Hcy＜15μmol/L，167례）화B조（Hcy≥15μmol/L，37례）；근거ABI수평분위비 PAD 조（0.9＜ABI≤1.3，140례）、PAD조（ABI≤0.9，19례）화동맥경화조（ABI>1.3，45례），비교불동조간Hcy화ABI수평적변화정황。결과동맥경화조환자혈청Hcy최고，PAD조차지，비PAD조혈청Hcy최저，삼조량량비교，차이균유통계학의의（P＜0.05）；B조환자이상ABI적비솔명현고우A조，차이유통계학의의（P＜0.01）。결론혈청Hcy여2형당뇨병PAD관계밀절，유망성위당뇨병PAD적혈청표지물。
Objective To investigate the correlation of homocysteine (Hcy) and ankle brachial index (ABI) in evalua-tion of diabetic peripheral artery disease. Methods ABI and homocysteine were measured in 204 Type 2 diabetic patients from Auguest 2011 to June 2012 in Xiamen No.2 Hospital. According to serum Hcy concentrations ,the patients were divided into group A (Hcy<15μmol/L,167 cases),and group B (Hcy≥15μmol/L,37 cases).According to ABI,the patients were divided into non-PAD(0.9<ABI≤1.30,140 cases),PAD group(ABI≤0.9,19 cases),and the atherosclerosis group(ABI>1.3,45 cases). Results The plasma serum Hcy concentrations in the atherosclerosis group was the highest,followed by PAD group,non-PAD group with the lowest plasma serum Hcy. The were statistical significance in difference (P<0.05). The incidence rate of abnormal ABI of group B were obviously higher that of the group A,whose difference had stastical significance(P<0.01). Conclusion The plasma Hcy is closely related to diabetic peripheral artery disease(PAD),which may be a serum marker for predicting diabetic PAD.