中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2015年
2期
152-155
,共4页
干细胞%发育毒性%体外模型%胚胎干细胞
榦細胞%髮育毒性%體外模型%胚胎榦細胞
간세포%발육독성%체외모형%배태간세포
Stem cells%Developmental toxicity%In v itro model%Embryonic stem cell
干细胞是一种原始细胞，具有自我更新能力和多向分化潜能。目前，由于环境和药物等外在因素的影响，畸形新生儿的比例逐年升高，建立准确、便捷、高效的发育毒性体外模型来评价预测各种化合物的发育毒性是亟待解决的难点问题。应用各类干细胞预测外在因素对机体的发育毒性，其优势远大于其他检测毒性方法。本文就近年来基于干细胞建立发育毒性体外模型的研究进行综述。
榦細胞是一種原始細胞，具有自我更新能力和多嚮分化潛能。目前，由于環境和藥物等外在因素的影響，畸形新生兒的比例逐年升高，建立準確、便捷、高效的髮育毒性體外模型來評價預測各種化閤物的髮育毒性是亟待解決的難點問題。應用各類榦細胞預測外在因素對機體的髮育毒性，其優勢遠大于其他檢測毒性方法。本文就近年來基于榦細胞建立髮育毒性體外模型的研究進行綜述。
간세포시일충원시세포，구유자아경신능력화다향분화잠능。목전，유우배경화약물등외재인소적영향，기형신생인적비례축년승고，건립준학、편첩、고효적발육독성체외모형래평개예측각충화합물적발육독성시극대해결적난점문제。응용각류간세포예측외재인소대궤체적발육독성，기우세원대우기타검측독성방법。본문취근년래기우간세포건립발육독성체외모형적연구진행종술。
Stem cells are the original cells with multi-potency and self-renewal capability. Recently, due to the ad-verse effects of environmental and external factors such as drugs, the ratio of deformed newborns increased year by year. It is a difficult problem to be solved, which establishing the accurate, convenient, efficient in v itro model of devel-opmental toxicity to evaluate and predict developmental toxicity of various compounds. Kinds of stem cells were applied to evaluate and predict the development toxicity of external factors on the body, which have far more advantages than other toxicity tests. This article reviewed the recent research about in v itro models of developmental toxicity based on various stem cells.
