中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
1期
72-74
,共3页
盐酸美沙酮片%癌症%疼痛
鹽痠美沙酮片%癌癥%疼痛
염산미사동편%암증%동통
Methadone hydrochloride tablet%Cancer%Pain
目的：观察盐酸美沙酮片(美沙酮)治疗中重度癌性疼痛的临床效果、不良反应及生活质量改善情况。方法42例中重度癌性疼痛患者给予美沙酮镇痛治疗，初始剂量5 mg/12 h，根据疼痛情况调整剂量，直至患者无痛或基本无痛，每位患者至少治疗15 d以上。观察患者的疼痛缓解情况、生活质量评分及不良反应。结果42例患者经过个体化给药后确定最终剂量为5~70 mg，每12小时1次，绝大部分患者疼痛达到明显缓解以上，疼痛的总缓解率为90.5%，其中完全缓解11例(26.2%)，明显缓解27例(64.3%)，对中度疼痛的缓解率为93.8%，重度疼痛的缓解率为88.5%。治疗前中位KPS评分为50分，治疗后中位KPS评分为75分，患者的生活质量明显改善(P<0.05)。全组KPS评分9例(21.4%)明显改善，13例(31.0%)有改善，20例(47.6%)达到稳定，无评分下降病例；不良反应少且轻微。结论美沙酮治疗中重度癌性疼痛安全有效，不良反应发生率较低，能够明显提高患者的生活质量。
目的：觀察鹽痠美沙酮片(美沙酮)治療中重度癌性疼痛的臨床效果、不良反應及生活質量改善情況。方法42例中重度癌性疼痛患者給予美沙酮鎮痛治療，初始劑量5 mg/12 h，根據疼痛情況調整劑量，直至患者無痛或基本無痛，每位患者至少治療15 d以上。觀察患者的疼痛緩解情況、生活質量評分及不良反應。結果42例患者經過箇體化給藥後確定最終劑量為5~70 mg，每12小時1次，絕大部分患者疼痛達到明顯緩解以上，疼痛的總緩解率為90.5%，其中完全緩解11例(26.2%)，明顯緩解27例(64.3%)，對中度疼痛的緩解率為93.8%，重度疼痛的緩解率為88.5%。治療前中位KPS評分為50分，治療後中位KPS評分為75分，患者的生活質量明顯改善(P<0.05)。全組KPS評分9例(21.4%)明顯改善，13例(31.0%)有改善，20例(47.6%)達到穩定，無評分下降病例；不良反應少且輕微。結論美沙酮治療中重度癌性疼痛安全有效，不良反應髮生率較低，能夠明顯提高患者的生活質量。
목적：관찰염산미사동편(미사동)치료중중도암성동통적림상효과、불량반응급생활질량개선정황。방법42례중중도암성동통환자급여미사동진통치료，초시제량5 mg/12 h，근거동통정황조정제량，직지환자무통혹기본무통，매위환자지소치료15 d이상。관찰환자적동통완해정황、생활질량평분급불량반응。결과42례환자경과개체화급약후학정최종제량위5~70 mg，매12소시1차，절대부분환자동통체도명현완해이상，동통적총완해솔위90.5%，기중완전완해11례(26.2%)，명현완해27례(64.3%)，대중도동통적완해솔위93.8%，중도동통적완해솔위88.5%。치료전중위KPS평분위50분，치료후중위KPS평분위75분，환자적생활질량명현개선(P<0.05)。전조KPS평분9례(21.4%)명현개선，13례(31.0%)유개선，20례(47.6%)체도은정，무평분하강병례；불량반응소차경미。결론미사동치료중중도암성동통안전유효，불량반응발생솔교저，능구명현제고환자적생활질량。
Objective To observe the clinical effect,adverse reaction,and improvement of patient’s living quality of methadone hydrochloride tablet (methadone) treating moderate and severe cancer pain. Methods Forty-two patients suf-fering from moderate or severe cancer pain were treated by methadone at an initial dosage of 5 mg/12 h.According to severity of pain,the dosage of methadone was adjusted until these patients didn’t feel pain or basically had no sensation of pain.The course of treatment for each participant lasted at least 15 days.At the same time,pain relief and quality of life were scored,and adverse reaction were observed. Results After 42 patients were given the individualized drug ad-ministration,the final dosage was set from 5 to 70 mg,at an interval of 12 h.After taking methadone,the vast majority of patients with pain was more than significantly alleviate,and the total alleviation rate of pain was 90.5%,of which com-plete alleviation in 11 cases (26.2%) and obvious relief in 27 cases (64.3%).The alleviation rate of pain in moderate degree was 93.8%,while for severe pain,the alleviation rate was 88.5%.Before treatment,the mean KPS score was 50 points,after taking methadone,the mean KPS score reached 75 points,the quality of life was greatly improved (P<0.05). Based on KPS score, great improvement was in 9 cases (21.4%),improvement in 13 (31.0%),and stabilization in 20 (47.6%),no case occurred with scoring decreasing.There were few adverse reactions that were quite slight. Conclusion Methadone treating moderate and severe pain is safe and effective with low incidence rate of adverse reactions,it can remarkably improve patient’s life of quality.
