CAJ | 학술논문

目的：探讨幽门螺杆菌感染与儿童过敏性紫癜的相关性，寻求过敏性紫癜的病因治疗方法。方法对2010年1月~2013年12月过敏性紫癜患儿，特别是腹型过敏性紫癜及反复发作过敏性紫癜患儿及健康儿童行13C尿素呼气试验检测幽门螺杆菌；对检测幽门螺杆菌阳性病例随机分实验组和常规组，实验组在常规治疗的基础上进行抗幽门螺杆菌治疗，常规组予常规治疗，均随访，并比较两组复发率。结果过敏性紫癜患儿特别是腹型及反复发作患儿幽门螺杆菌感染率明显高于健康儿童，差异有统计学意义(P<0.05)。随访实验组复发率较常规组明显降低(P<0.05)。结论幽门螺杆菌感染可能是过敏性紫癜的发病诱因之一，对过敏性紫癜患儿尤其反复发作及腹型过敏性紫癜患儿行幽门螺杆菌检测、根除幽门螺杆菌治疗可降低过敏性紫癜的复发率。
목적：탐토유문라간균감염여인동과민성자전적상관성，심구과민성자전적병인치료방법。방법대2010년1월~2013년12월과민성자전환인，특별시복형과민성자전급반복발작과민성자전환인급건강인동행13C뇨소호기시험검측유문라간균；대검측유문라간균양성병례수궤분실험조화상규조，실험조재상규치료적기출상진행항유문라간균치료，상규조여상규치료，균수방，병비교량조복발솔。결과과민성자전환인특별시복형급반복발작환인유문라간균감염솔명현고우건강인동，차이유통계학의의(P<0.05)。수방실험조복발솔교상규조명현강저(P<0.05)。결론유문라간균감염가능시과민성자전적발병유인지일，대과민성자전환인우기반복발작급복형과민성자전환인행유문라간균검측、근제유문라간균치료가강저과민성자전적복발솔。
Objective To invetigate the relationship between Helicobacter pylori (Hp)infection and Henoch-Schonlein purpura (HSP)in children in order to find out the etiological treatment for HSP. Methods Hp was detected by 13C-sub-strate urea expiratory in children with HSP (especially the abdominal and recurrent HSP children)and and healthy chil-dren from January 2010 to December 2013.Children with Hp were randomly divided into experimental group and con-ventional group.Conventional treatment was used in conventional group,Hp eradication therapy together with convention-al therapy were applied in experimental group.All children were followed up,the recurrence rate of two groups was compared. Results Hp infection rate of children with HSP (especially the abdominal and recurrent HSP children) were significantly higher than that of normal children,with statistical difference (P<0.05).The recurrence rate of experimental group was significantly lower than that of conventional group (P<0.05). Conclusion Hp infection may be one of trigger-ing events which caused HSP.Detection and eradication of Hp on children with HSP (especially the abdominal and re-current HSP children)can reduce recurrence rate of HSP.