中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
1期
117-119
,共3页
急性有机磷农药中毒%盐酸戊乙奎醚%阿托品%不良反应
急性有機燐農藥中毒%鹽痠戊乙奎醚%阿託品%不良反應
급성유궤린농약중독%염산무을규미%아탁품%불량반응
Acute organophosphorus pesticide poisoning%Penehyclidine hydrochloride%Atropine%Adverse reaction
目的：探讨盐酸戊乙奎醚治疗急性有机磷农药中毒(AOPP)的临床效果及安全性。方法将120例纳入研究的AOPP患者随机分成两组：观察组60例，应用盐酸戊乙奎醚治疗；对照组60例，应用阿托品治疗。比较两组的解毒效果及不良反应发生率。结果观察组的总有效率为93.33%，对照组为80.00%，观察组的疗效明显优于对照组(P<0.05)；观察组的M样症状持续时间为(1.70±0.45)h、N样症状持续时间为(6.38±2.09)h和中枢神经系统症状持续时间(12.50±3.22)h，均显著短于对照组的(2.31±0.52)、(10.25±4.88)、(18.37±3.16)h(P<0.05)；观察组患者所需的意识障碍恢复时间为(23.46±11.30)h、ChE活性恢复时间为(46.81±13.27)h、住院天数为(7.03±2.85)d，均显著短于对照组的(40.58±12.35)h、(63.50±18.94)h、(11.52±3.06)d(P<0.05)；观察组出现心动过速、躁动、视力模糊、尿潴留等不良反应发生率均明显低于对照组(P<0.05)。结论盐酸戊乙奎醚治疗AOPP比阿托品更安全、有效。
目的：探討鹽痠戊乙奎醚治療急性有機燐農藥中毒(AOPP)的臨床效果及安全性。方法將120例納入研究的AOPP患者隨機分成兩組：觀察組60例，應用鹽痠戊乙奎醚治療；對照組60例，應用阿託品治療。比較兩組的解毒效果及不良反應髮生率。結果觀察組的總有效率為93.33%，對照組為80.00%，觀察組的療效明顯優于對照組(P<0.05)；觀察組的M樣癥狀持續時間為(1.70±0.45)h、N樣癥狀持續時間為(6.38±2.09)h和中樞神經繫統癥狀持續時間(12.50±3.22)h，均顯著短于對照組的(2.31±0.52)、(10.25±4.88)、(18.37±3.16)h(P<0.05)；觀察組患者所需的意識障礙恢複時間為(23.46±11.30)h、ChE活性恢複時間為(46.81±13.27)h、住院天數為(7.03±2.85)d，均顯著短于對照組的(40.58±12.35)h、(63.50±18.94)h、(11.52±3.06)d(P<0.05)；觀察組齣現心動過速、躁動、視力模糊、尿潴留等不良反應髮生率均明顯低于對照組(P<0.05)。結論鹽痠戊乙奎醚治療AOPP比阿託品更安全、有效。
목적：탐토염산무을규미치료급성유궤린농약중독(AOPP)적림상효과급안전성。방법장120례납입연구적AOPP환자수궤분성량조：관찰조60례，응용염산무을규미치료；대조조60례，응용아탁품치료。비교량조적해독효과급불량반응발생솔。결과관찰조적총유효솔위93.33%，대조조위80.00%，관찰조적료효명현우우대조조(P<0.05)；관찰조적M양증상지속시간위(1.70±0.45)h、N양증상지속시간위(6.38±2.09)h화중추신경계통증상지속시간(12.50±3.22)h，균현저단우대조조적(2.31±0.52)、(10.25±4.88)、(18.37±3.16)h(P<0.05)；관찰조환자소수적의식장애회복시간위(23.46±11.30)h、ChE활성회복시간위(46.81±13.27)h、주원천수위(7.03±2.85)d，균현저단우대조조적(40.58±12.35)h、(63.50±18.94)h、(11.52±3.06)d(P<0.05)；관찰조출현심동과속、조동、시력모호、뇨저류등불량반응발생솔균명현저우대조조(P<0.05)。결론염산무을규미치료AOPP비아탁품경안전、유효。
Objective To investigate the clinical effect and safety of penehyclidine hydrochloride treating acute organophosphorus pesticide poisoning (AOPP). Methods 120 cases with AOPP were randomly divided into the two groups.The observation group (n=60) was given penehyclidine hydrochloride,and the control group was given atropine. The detoxifying effect and the incidence rate of adverse reaction in the two groups were compared. Results The total ef-fective rate of the observation group was 93.33%,while the control group was 80.00%,the curative effect of the observa-tion group was obviously better than that in the control group (P<0.05);the muscarinic-like symptom duration was (1.70±0.45) h,nicotine-like symptom duration was (6.38±2.09) h,and duration of symptom of central nervous system was (12.50±3.22) h in the observation group,above-mentioned indicators in the observation was significantly shorter than that in the control group respectively [(2.31±0.52),(10.25±4.88),(18.37±3.16) h] (P<0.05);the disturbance consciousness recovery time was (23.46±11.30) h,ChE activity recovery time was (46.81±13.27) h and hospital stay was (7.03±2.85) d in the obser-vation group,above-mentioned indicators in the observation group was significantly shorter than that in the control group respectively [(40.58±12.35)h, (63.50±18.94)h,(11.52±3.06)d] (P<0.05);the incidence rate of heartbeat tachycardia, agitation,blurred vision,retention of urine and so on in the observation group was lower than that in the control group re-spectively (P<0.05). Conclusion Penehyclidine hydrochloride used in rescuing AOPP is safer and more effective.
