中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
1期
109-111
,共3页
急性胰腺炎%奥曲肽%乌司他丁%临床效果
急性胰腺炎%奧麯肽%烏司他丁%臨床效果
급성이선염%오곡태%오사타정%림상효과
Acute pancreatitis%Octreotide%Ulinastatin%Clinical effect
目的：探讨国产奥曲肽联合乌司他丁治疗急性胰腺炎的有效性和安全性，为临床用药和急性胰腺炎治疗积累经验。方法选取本院2011年1月~2013年12月收治的187例急性胰腺炎患者为研究对象，入院后按照抽签随机取样法将其分为对照组(n=94)和观察组(n=93)。对照组给予奥曲肽皮下注射，0.1 mg/次，2次/d，观察组在对照组基础上给予乌司他丁静脉输注，100000 U/次，1次/d。比较两组的相关临床指标(腹胀、腹部压痛缓解时间，血、尿淀粉酶恢复正常时间)改善情况及APACHEⅡ评分。比较两组的总有效率、严重并发症发生率、病死率及不良反应发生率。结果观察组的相关临床指标改善时间均短于对照组(P<0.05)，APACHEⅡ评分低于对照组(P<0.05)。观察组的总有效率显著高于对照组(92.5%v s 77.6%，χ2=8.06，P=0.007)，严重并发症发生率显著低于对照组(4.3% vs 14.9%，χ2=6.03，P=0.023)，不良反应发生率高于对照组(5.4% vs 3.2%)，但差异无统计学意义(χ2=0.545，P=0.497)。结论国产奥曲肽联合乌司他丁治疗能有效改善急性胰腺炎患者的相关临床指标，有效率显著高于单纯使用国产奥曲肽，且安全性高，值得临床推广应用。
目的：探討國產奧麯肽聯閤烏司他丁治療急性胰腺炎的有效性和安全性，為臨床用藥和急性胰腺炎治療積纍經驗。方法選取本院2011年1月~2013年12月收治的187例急性胰腺炎患者為研究對象，入院後按照抽籤隨機取樣法將其分為對照組(n=94)和觀察組(n=93)。對照組給予奧麯肽皮下註射，0.1 mg/次，2次/d，觀察組在對照組基礎上給予烏司他丁靜脈輸註，100000 U/次，1次/d。比較兩組的相關臨床指標(腹脹、腹部壓痛緩解時間，血、尿澱粉酶恢複正常時間)改善情況及APACHEⅡ評分。比較兩組的總有效率、嚴重併髮癥髮生率、病死率及不良反應髮生率。結果觀察組的相關臨床指標改善時間均短于對照組(P<0.05)，APACHEⅡ評分低于對照組(P<0.05)。觀察組的總有效率顯著高于對照組(92.5%v s 77.6%，χ2=8.06，P=0.007)，嚴重併髮癥髮生率顯著低于對照組(4.3% vs 14.9%，χ2=6.03，P=0.023)，不良反應髮生率高于對照組(5.4% vs 3.2%)，但差異無統計學意義(χ2=0.545，P=0.497)。結論國產奧麯肽聯閤烏司他丁治療能有效改善急性胰腺炎患者的相關臨床指標，有效率顯著高于單純使用國產奧麯肽，且安全性高，值得臨床推廣應用。
목적：탐토국산오곡태연합오사타정치료급성이선염적유효성화안전성，위림상용약화급성이선염치료적루경험。방법선취본원2011년1월~2013년12월수치적187례급성이선염환자위연구대상，입원후안조추첨수궤취양법장기분위대조조(n=94)화관찰조(n=93)。대조조급여오곡태피하주사，0.1 mg/차，2차/d，관찰조재대조조기출상급여오사타정정맥수주，100000 U/차，1차/d。비교량조적상관림상지표(복창、복부압통완해시간，혈、뇨정분매회복정상시간)개선정황급APACHEⅡ평분。비교량조적총유효솔、엄중병발증발생솔、병사솔급불량반응발생솔。결과관찰조적상관림상지표개선시간균단우대조조(P<0.05)，APACHEⅡ평분저우대조조(P<0.05)。관찰조적총유효솔현저고우대조조(92.5%v s 77.6%，χ2=8.06，P=0.007)，엄중병발증발생솔현저저우대조조(4.3% vs 14.9%，χ2=6.03，P=0.023)，불량반응발생솔고우대조조(5.4% vs 3.2%)，단차이무통계학의의(χ2=0.545，P=0.497)。결론국산오곡태연합오사타정치료능유효개선급성이선염환자적상관림상지표，유효솔현저고우단순사용국산오곡태，차안전성고，치득림상추엄응용。
Objective To investigate the effectiveness and safety of the homemade octreotide combined with ulinastatin in the treatment of acute pancreatitis in order to accumulate experience for clinical medication and treatment of acute pancreatitis. Methods 187 patients with acute pancreatitis treated in our hospital from January 2011 to December 2013 were selected as the research objects and they were divided into the control group (n=94) and observation group (n=93) according to the random sampling of lottery law after admission.The control group was given subcutaneous injection of oc-treotide,0.1 mg/time,twice a day,while the observation group was treated with ulinastatin intravenous infusion,100 000 U/time, once a day on the basis of the treatment of control group.The improvement of clinical indicators (alleviation time of ab-dominal distension,abdominal tenderness and recovery time of blood amylase,urine amylase returning to normal) and APACHE II score in the two groups were compared.The total effective rate,incidence rate of severe complications,the fatality rate,the incidence rate of adverse reactions in the two groups were compared. Results The improvement time of the clinical indicators of the observation group was shorter than that of the control group (P<0.05) and the APACHE IIscore was lower than that of the control group (P<0.05).The total effective rate in the observation group was significantly higher than that of the control group (92.5%v s 77.6%,χ2=8.06,P=0.007).The incidence rate of severe complications was significantly lower than that of control group (4.3% vs 14.9%,χ2=6.03,P=0.023).The incidence rate of adverse reaction was higher than that of the control group (5.4% vs 3.2%),but the difference was not statistically significant (χ2=0.545, P=0.497). Conclusion Homemade octreotide combined with ulinastatin can effectively improve the related clinical indi-cators of the patients with acute pancreatitis and its effective rate is significantly higher than that of only one kind of medicine and the safety was high.It is worthy of clinical promotion and application.
