中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
1期
106-108
,共3页
肝硬化%上消化道出血%醋酸奥曲肽%硝酸甘油
肝硬化%上消化道齣血%醋痠奧麯肽%硝痠甘油
간경화%상소화도출혈%작산오곡태%초산감유
Cirrhosis%Upper gastrointestinal bleeding%Octreotide Acetate%Nitroglycerin
目的：探讨醋酸奥曲肽联合硝酸甘油治疗肝硬化继发上消化道出血的临床效果。方法选取本院2012年1月~2014年1月收治的肝硬化继发上消化道出血患者80例，采用双盲法将患者分为观察组和对照组。两组均给予常规治疗，对照组在常规治疗基础上给予醋酸奥曲肽治疗，观察组在对照组基础上加用硝酸甘油治疗，比较两组的临床疗效。结果观察组的总有效率为95.0%，显效时间、停止出血时间分别为(5.62±1.24)、(10.36±2.38)h，治疗后的门静脉、脾静脉血流量分别为(546.5±169.3)、(256.3±103.2)ml/min，与对照组比较，差异有统计学意义(P<0.05)；两组治疗期间均未发生严重不良反应。结论醋酸奥曲肽联合硝酸甘油治疗肝硬化继发上消化道出血可快速止血、降低门脉压力，达到有效控制出血的目的，效果显著。
目的：探討醋痠奧麯肽聯閤硝痠甘油治療肝硬化繼髮上消化道齣血的臨床效果。方法選取本院2012年1月~2014年1月收治的肝硬化繼髮上消化道齣血患者80例，採用雙盲法將患者分為觀察組和對照組。兩組均給予常規治療，對照組在常規治療基礎上給予醋痠奧麯肽治療，觀察組在對照組基礎上加用硝痠甘油治療，比較兩組的臨床療效。結果觀察組的總有效率為95.0%，顯效時間、停止齣血時間分彆為(5.62±1.24)、(10.36±2.38)h，治療後的門靜脈、脾靜脈血流量分彆為(546.5±169.3)、(256.3±103.2)ml/min，與對照組比較，差異有統計學意義(P<0.05)；兩組治療期間均未髮生嚴重不良反應。結論醋痠奧麯肽聯閤硝痠甘油治療肝硬化繼髮上消化道齣血可快速止血、降低門脈壓力，達到有效控製齣血的目的，效果顯著。
목적：탐토작산오곡태연합초산감유치료간경화계발상소화도출혈적림상효과。방법선취본원2012년1월~2014년1월수치적간경화계발상소화도출혈환자80례，채용쌍맹법장환자분위관찰조화대조조。량조균급여상규치료，대조조재상규치료기출상급여작산오곡태치료，관찰조재대조조기출상가용초산감유치료，비교량조적림상료효。결과관찰조적총유효솔위95.0%，현효시간、정지출혈시간분별위(5.62±1.24)、(10.36±2.38)h，치료후적문정맥、비정맥혈류량분별위(546.5±169.3)、(256.3±103.2)ml/min，여대조조비교，차이유통계학의의(P<0.05)；량조치료기간균미발생엄중불량반응。결론작산오곡태연합초산감유치료간경화계발상소화도출혈가쾌속지혈、강저문맥압력，체도유효공제출혈적목적，효과현저。
Objective To investigate the clinical effect of octreotide acetate combined with nitroglycerin treating cirrho-sis complicated with the upper gastrointestinal bleeding. Methods 80 patients with cirrhosis complicated with the upper gastrointestinal bleeding admitted into our hospital from January 2012 to January 2014 were selected,and they were di-vided into the observation group and control group according to double-blind method.The two group were given the conventional treatment,the control group was treated with octreotide acetate on the basis of the conventional treatment, the observation group was treated with nitroglycerin on the basis of the control group,the curative effect in the two groups was compared. Results In the observation group,the total effective rate was 95.0%,the markedly effective time and the time of bleeding stop was (5.62±1.24) h and (10.36±2.38) h respectively,portal blood flow and splenic vein blood flow after treatment was (546.5±169.3) ml/min and (256.3±103.2) ml/min respectively,and there was a statistical difference of above-mentioned indicators in the two groups (P<0.05).There were no serious adverse events occurred in the two groups during treatment. Conclusion Octreotide acetate combined with nitroglycerin treating cirrhosis compli-cated with the upper gastrointestinal bleeding has a significant effect,and can quickly stop bleeding,reduce portal pres-sure to achieve the purpose of effective control of bleeding.
