CAJ | 학술논문

目的：探讨匹多莫德口服液治疗小儿支原体肺炎的临床效果。方法回顾性分析本院2010年1月~2014年1月收治的支原体肺炎患儿200例的临床资料。根据治疗方法不同将患者分为两组，两组均予退热、止咳、化痰处理，同时配以吸氧、纠正水电解质紊乱和维持酸碱平衡等常规治疗，对照组在此基础上采用阿奇霉素治疗,观察组在常规治疗基础上予匹多莫德治疗。比较两组的相关指标和临床疗效。结果观察组的肺部啰音消失时间为(96±15)h，肺部炎症吸收时间为(79±21)h，对照组分别为(168±18)、(164±24)h，观察组的肺部啰音消失时间、肺部炎症吸收时间分别低于对照组，差异有统计学意义(P<0.05)；观察组的总有效率(95.0%)高于对照组(78.0%)，差异有统计学意义(P<0.05)；观察组治疗后的血清IgA、IgG、IgM水平与对照组比较，差异有统计学意义(P<0.05)；观察组治疗后的血清CD3+、CD4+、CD8+、CD4+/CD8+水平与对照组比较，差异有统计学意义(P<0.05)。结论匹多莫德口服液治疗小儿支原体肺炎效果显著，值得在儿科推广。
목적：탐토필다막덕구복액치료소인지원체폐염적림상효과。방법회고성분석본원2010년1월~2014년1월수치적지원체폐염환인200례적림상자료。근거치료방법불동장환자분위량조，량조균여퇴열、지해、화담처리，동시배이흡양、규정수전해질문란화유지산감평형등상규치료，대조조재차기출상채용아기매소치료,관찰조재상규치료기출상여필다막덕치료。비교량조적상관지표화림상료효。결과관찰조적폐부라음소실시간위(96±15)h，폐부염증흡수시간위(79±21)h，대조조분별위(168±18)、(164±24)h，관찰조적폐부라음소실시간、폐부염증흡수시간분별저우대조조，차이유통계학의의(P<0.05)；관찰조적총유효솔(95.0%)고우대조조(78.0%)，차이유통계학의의(P<0.05)；관찰조치료후적혈청IgA、IgG、IgM수평여대조조비교，차이유통계학의의(P<0.05)；관찰조치료후적혈청CD3+、CD4+、CD8+、CD4+/CD8+수평여대조조비교，차이유통계학의의(P<0.05)。결론필다막덕구복액치료소인지원체폐염효과현저，치득재인과추엄。
Objective To investigate the clinical effect of pidotimod oral liquid treating Mycoplasma pneumonia in children. Methods The clinical data of 200 children with Mycoplasma pneumonia treated in our hospital from January 2010 to January 2014were analyzed retrospectively.According to the different treatment methods,they were divided into the two groups,the two groups were given the conventional treatment,such as abatement of fever,relieving cough, reduc-ing phlegm,at the same time,they were treated with oxygen uptake,correcting water and electrolyte disorders,maintaining acid-base balance and so on,the control group was treated with azithromycin,the observation group was given pidotimod on the basis of the conventional treatment.The related indictors and curative effect in the two groups were compared. Results The disappearance time of lung rale were (96±15) hours,the absorption time of lung inflammation were (79±21) hours in the observation group and it was (168±18) hours,(164±24) hours respectively in the control group,the disap-pearance time of lung rale,the absorption time of lung inflammation in the observation group was higher than that in the control group respectively,and there was a statistical difference (P<0.05).The total effective rate of the observation group (95.0%) was higher than that of the control group (78.0%),and there was a statistical difference (P<0.05).After treat-ment,there was a statistical difference of serum IgA,IgG,Ig-M level in the two groups (P<0.05);after treatment,there was a statistical difference of serum CD3+,CD4+,CD8+,CD4+/CD8+of the two groups (P<0.05). Conclusion The effect of pidoti-mod oral liquid treating Mycoplasma pneumonia in children is significant,and it is worthy of promotion in department of pediatrics.