CAJ | 학술논문

目的：探讨新鲜冰冻血浆强化的早期目标导向液体复苏（ early goal-directed fluid therapy，EGDT）方案对重症急性胰腺炎（severe acute pancreatitis，SAP）的疗效。方法2010年1月至2014年6月，按照连续采样的方法收集我科就诊的重症急性胰腺炎患者79例，所有患者随机分为接受一般液体复苏治疗的对照组（A 组，27例），早期目标导向液体复苏治疗的试验1组（B 组，30例）和新鲜冰冻血浆强化的早期目标导向液体复苏治疗的试验2组（C 组，22例）。组间患者一般情况构成差异无统计学意义。比较组间患者 ICU 入住时间，腹腔间隔室综合征（abdominal com-partment syndrome，ACS）、MODS 发生率以及住院死亡率的差异。结果与 A 组相比，B、C 组患者ICU 入住时间较短，ACS、MODS 发生率及病死率较低，组间差异有统计学意义（P <0.05）；与 B 组相比，C 组患者 ICU 入住时间较短，ACS、MODS 发生率及病死率较低，组间差异有统计学意义（P <0.05）。结论新鲜冰冻血浆强化的 EGDT 方案有助于缩短 SAP 患者 ICU 入住时间，降低 ACS、MODS 发生率及病死率。
목적：탐토신선빙동혈장강화적조기목표도향액체복소（ early goal-directed fluid therapy，EGDT）방안대중증급성이선염（severe acute pancreatitis，SAP）적료효。방법2010년1월지2014년6월，안조련속채양적방법수집아과취진적중증급성이선염환자79례，소유환자수궤분위접수일반액체복소치료적대조조（A 조，27례），조기목표도향액체복소치료적시험1조（B 조，30례）화신선빙동혈장강화적조기목표도향액체복소치료적시험2조（C 조，22례）。조간환자일반정황구성차이무통계학의의。비교조간환자 ICU 입주시간，복강간격실종합정（abdominal com-partment syndrome，ACS）、MODS 발생솔이급주원사망솔적차이。결과여 A 조상비，B、C 조환자ICU 입주시간교단，ACS、MODS 발생솔급병사솔교저，조간차이유통계학의의（P <0.05）；여 B 조상비，C 조환자 ICU 입주시간교단，ACS、MODS 발생솔급병사솔교저，조간차이유통계학의의（P <0.05）。결론신선빙동혈장강화적 EGDT 방안유조우축단 SAP 환자 ICU 입주시간，강저 ACS、MODS 발생솔급병사솔。
Objective To evaluate the effect of early goal-directed fluid therapy with fresh frozen plasma in severe acute pancreatitis(SAP). Methods From January 2010 to June 2014,79 SAP patients were enrolled according to the continuous sampling method. All the patients were randomly divided into a control group who accept the traditional fluid therapy(group A),an experimental group 1 who accept early goal-directed fluid therapy(group B),and an experimental group 2 who accept the early goal-directed fluid therapy with fresh frozen plasma(group C). There were no significant differences of general conditions a-mong groups. The differences of ICU admission,mortality and occurrence rate of abdominal compartment syndrome(ACS)and MODS were compared among groups. Results Compared with group A,group B and C have a shorter length of ICU admission,a lower mortality and a lower occurrence rate of ACS and MODS (P < 0. 05). Compared with group B,group C have a shorter length of ICU admission,a lower mortality and a lower occurrence rate of ACS and MODS(P < 0. 05). Conclusion The method of early goal-direct-ed fluid therapy with fresh frozen plasma will contribute to shorten the length of ICU admission and reduce mortality and occurrence rate of ACS and MODS for patients with SAP.