CAJ | 학술논문

目的：：通过对比中重度阻塞性睡眠呼吸暂停低通气综合征患者持续气道正压通气治疗前后肝纤维化标志物的变化，探讨阻塞性睡眠呼吸暂停低通气综合征与肝纤维化之间的关系。方法：选取2010年12月至2013年6月期间在我院门诊和病房确诊为中重度阻塞性睡眠呼吸暂停低通气综合征并行家庭无创通气治疗的患者作为研究对象。检测所有患者治疗前后体质量指数、呼吸暂停低通气指数、最低血氧饱和度、平均血氧饱和度、透明质酸、Ⅲ型前胶原、IV型胶原、层黏连蛋白的水平。结果：所有中重度阻塞性睡眠呼吸暂停低通气综合征患者的体质量指数水平在治疗前后无显著差异(P>0.05)；治疗后的呼吸暂停低通气指数水平较治疗前显著下降，平均血氧饱和度、最低血氧饱和度水平显著升高(P<0.05)；治疗后的透明质酸、Ⅲ型前胶原、Ⅳ型胶原和层黏连蛋白水平较治疗前均显著下降(P<0.05)。结论：治疗阻塞性睡眠呼吸暂停低通气综合征可以改善肝纤维化程度。
목적：：통과대비중중도조새성수면호흡잠정저통기종합정환자지속기도정압통기치료전후간섬유화표지물적변화，탐토조새성수면호흡잠정저통기종합정여간섬유화지간적관계。방법：선취2010년12월지2013년6월기간재아원문진화병방학진위중중도조새성수면호흡잠정저통기종합정병행가정무창통기치료적환자작위연구대상。검측소유환자치료전후체질량지수、호흡잠정저통기지수、최저혈양포화도、평균혈양포화도、투명질산、Ⅲ형전효원、IV형효원、층점련단백적수평。결과：소유중중도조새성수면호흡잠정저통기종합정환자적체질량지수수평재치료전후무현저차이(P>0.05)；치료후적호흡잠정저통기지수수평교치료전현저하강，평균혈양포화도、최저혈양포화도수평현저승고(P<0.05)；치료후적투명질산、Ⅲ형전효원、Ⅳ형효원화층점련단백수평교치료전균현저하강(P<0.05)。결론：치료조새성수면호흡잠정저통기종합정가이개선간섬유화정도。
Objective: To investigate the change of continuous positive airway pressure ( CPAD ) treatment on markers of hepatic fibrosis in patients with severe and moderate obstructive sleep apnea hypopnea syndrome ( OSAHS) . Methods:According to AHI, We’ve selected the severe and moderate OSAHS group, from the patients ongoing monitoring of polysomnography in the sleep disorder center in Rugao People’s Hospital from December 2010 to June 2013. The BMI, AHI, LSaO2 , MSaO2 and plasma HA, PⅢP, ⅣC, LN levels of the patients were compared before and after CPAP treatment. Results: There was no significant difference of the BMI levels before and after CPAP treatment (P >0. 05). The LSaO2 and MSaO2 levels were significantly reduced after CPAP treatment (P <0. 05). The AHI and plasma HA, PⅢP, ⅣC, LN levels of the patients were significantly increased after CPAP treatment ( P <0 . 05 ) . Conclusion: The CPAP treatment can improve hepatic fibrosis in OSAHS patients.