东南大学学报（医学版）
東南大學學報（醫學版）
동남대학학보（의학판）
JOURNAL OF SOUTHEAST UNIVERSITY(MEDICAL SCIENCE EDITION)
2015年
1期
110-112
,共3页
高血压%角膜%内皮细胞%形态学
高血壓%角膜%內皮細胞%形態學
고혈압%각막%내피세포%형태학
hypertension%corneal%endothelial cell%morphology
目的：：探讨原发性高血压病对角膜内皮的影响。方法：应用全自动角膜内皮细胞分析仪对296例348眼进行角膜厚度及内皮细胞形态检测。原发性高血压患者148例173眼,其中A组(Ⅰ、Ⅱ期)87例104眼,B组(Ⅲ、Ⅳ期)61例69眼；正常对照组148例175眼。各组之间年龄、性别差异无统计学意义,且均排除其他全身疾病史。对各组角膜内皮细胞的平均密度、六边形细胞比例、变异系数及中央角膜厚度进行统计学分析。结果：高血压组患者较正常对照组角膜内皮细胞变异系数和中央角膜厚度增加,六边形细胞比例以及中央角膜内皮细胞密度减少,差异具有统计学意义(P<0.05或P<0.01)；高血压B组与高血压A组相比较4项指标之间差异均有统计学意义(P<0.05或P<0.01)。结论：原发性高血压患者角膜内皮细胞形态结构存在异常,且随病变程度的加重而加重。对合并患有高血压的患者在进行内眼手术时应特别注意保护角膜内皮,防止角膜内皮功能失代偿。
目的：：探討原髮性高血壓病對角膜內皮的影響。方法：應用全自動角膜內皮細胞分析儀對296例348眼進行角膜厚度及內皮細胞形態檢測。原髮性高血壓患者148例173眼,其中A組(Ⅰ、Ⅱ期)87例104眼,B組(Ⅲ、Ⅳ期)61例69眼；正常對照組148例175眼。各組之間年齡、性彆差異無統計學意義,且均排除其他全身疾病史。對各組角膜內皮細胞的平均密度、六邊形細胞比例、變異繫數及中央角膜厚度進行統計學分析。結果：高血壓組患者較正常對照組角膜內皮細胞變異繫數和中央角膜厚度增加,六邊形細胞比例以及中央角膜內皮細胞密度減少,差異具有統計學意義(P<0.05或P<0.01)；高血壓B組與高血壓A組相比較4項指標之間差異均有統計學意義(P<0.05或P<0.01)。結論：原髮性高血壓患者角膜內皮細胞形態結構存在異常,且隨病變程度的加重而加重。對閤併患有高血壓的患者在進行內眼手術時應特彆註意保護角膜內皮,防止角膜內皮功能失代償。
목적：：탐토원발성고혈압병대각막내피적영향。방법：응용전자동각막내피세포분석의대296례348안진행각막후도급내피세포형태검측。원발성고혈압환자148례173안,기중A조(Ⅰ、Ⅱ기)87례104안,B조(Ⅲ、Ⅳ기)61례69안；정상대조조148례175안。각조지간년령、성별차이무통계학의의,차균배제기타전신질병사。대각조각막내피세포적평균밀도、륙변형세포비례、변이계수급중앙각막후도진행통계학분석。결과：고혈압조환자교정상대조조각막내피세포변이계수화중앙각막후도증가,륙변형세포비례이급중앙각막내피세포밀도감소,차이구유통계학의의(P<0.05혹P<0.01)；고혈압B조여고혈압A조상비교4항지표지간차이균유통계학의의(P<0.05혹P<0.01)。결론：원발성고혈압환자각막내피세포형태결구존재이상,차수병변정도적가중이가중。대합병환유고혈압적환자재진행내안수술시응특별주의보호각막내피,방지각막내피공능실대상。
Objective: To investigate the effect of hypertension on corneal endothelial cells. Methods: The automatic corneal endothelial cells analytical application were used to detect the corneal thickness and endothelial cell morphology with 296 cases (348 eyes) . Patients with stages I and II hypertension were enrolled in the Group A while those with stages III and IV hypertension in the Group B. Of a total of 148 patients with hypertension (173 eyes) , 87 cases(104 eyes) were enrolled in the Group A while 61 cases(69 eyes) in the Group B. Among all the subjects, there were no statistical differences in gender, age, and the exclusion of other systemic disease history. Statistical analysis was made on the corneal endothelial cells into the average density, percentage of hexagonal cells, coefficient of variation and central corneal thickness. Results: Compared with normal controls, both coefficient of variation and central corneal thickness increased while percentage of hexagonal cells and central corneal endothelial cell densities decreased in patients with hypertension, with a significant difference (P<0. 05 or P<0. 01). Meanwhile, for hypertension, there were significant differences in four indicators between Groups A and B ( P<0 . 05 or P<0 . 01 ) . Conclusion:There are abnormal morphology of corneal endothelial cells in primary hypertension patients, which are aggravated with the severity of disease. So when the ophthalmologist conduct the intraocular operation with hypertension patients, they should pay special attention to the protection of the cornea endothelial to prevent corneal endothelial decompensation.
