CAJ | 학술논문

目的：：研究术中植入氟尿嘧啶缓释剂对大肝癌术后复发的预防作用。方法：对我院收治的100例大肝癌手术患者进行前瞻性临床随机对照研究，分为实验组和对照组，各50例。实验组在术中行肝切除创面和大网膜氟尿嘧啶缓释剂植入。观察两组术前一般资料，术后肝肾功能，出血、胆漏、切口裂开等手术并发症，恶心呕吐、白细胞下降等化疗不良反应，以及1年、3年复发率和生存时间。结果：两组间术后手术并发症、化疗相关不良反应差异均无统计学意义(均P>0.05)。实验组1年、3年的复发率分别为34%和54%，对照组分别为42%和70%，两组间差异无统计学意义(P>0.05)。两组生存函数间差异有统计学意义(P<0.05)。结论：术中植入缓释型氟尿嘧啶安全可行，可延长患者生存时间。
목적：：연구술중식입불뇨밀정완석제대대간암술후복발적예방작용。방법：대아원수치적100례대간암수술환자진행전첨성림상수궤대조연구，분위실험조화대조조，각50례。실험조재술중행간절제창면화대망막불뇨밀정완석제식입。관찰량조술전일반자료，술후간신공능，출혈、담루、절구렬개등수술병발증，악심구토、백세포하강등화료불량반응，이급1년、3년복발솔화생존시간。결과：량조간술후수술병발증、화료상관불량반응차이균무통계학의의(균P>0.05)。실험조1년、3년적복발솔분별위34%화54%，대조조분별위42%화70%，량조간차이무통계학의의(P>0.05)。량조생존함수간차이유통계학의의(P<0.05)。결론：술중식입완석형불뇨밀정안전가행，가연장환자생존시간。
Objective:To explore the effect of implanting sustained-release 5-fluorouracil during hepatectomy on the recurrence of large liver cancer. Methods:100 liver cancer patients undergoing hepatectomy were divided into experimental group ( n = 50 ) and control group ( n = 50 ) . Operative complications, adverse reaction of chemotherapy, recurrence rate and survival time were compared between the two groups. Results: There were no difference in operative complications and adverse reaction of chemotherapy between the two groups. All the cases were followed up for more than 3 years. 1-,3-year recurrence rates were 34% and 54% in experimental group respectively, 42% and 70% in control group respectively. There were no difference between them(P>0. 05). Survival time of experimental group was longer than control group with statistical difference ( P< 0 . 05 ) . Conclusion:Implanting sustained-release 5-fluorouracil can be used saftly during large liver cancer operation and can prolong survival time.