CAJ | 학술논문

目的：探讨糖耐量减低的认知功能以及在特定任务刺激下不同脑区的活动情况。方法对13例糖耐量减低（impaired glucose tolerance，IGT）患者和19名糖耐量正常（normal glucose tolerance，NGT）受试者进行认知、记忆评估及词语（文字、数字）工作记忆及客体（面孔）工作记忆任务下的功能性磁共振检查，分析脑激活图。结果①I GT患者的认知与N GT组相比，差异无统计学意义（t＝0.459，P＝0.635）。②与NGT组相比，IGT组在文字工作记忆中右侧颞叶、颞上回（brodmann area 22，BA22区）等脑区激活减弱（t＝55.81，P＝0.009）；数字工作记忆中，右侧豆状核、壳核等脑区激活减弱（t＝216.84，P＝0.009）；客体工作记忆中：右侧尾状核体激活减弱（t＝5.09，P＝0.008）。结论 IGT患者词语及客体工作记忆经典激活脑区可能存在损害。
목적：탐토당내량감저적인지공능이급재특정임무자격하불동뇌구적활동정황。방법대13례당내량감저（impaired glucose tolerance，IGT）환자화19명당내량정상（normal glucose tolerance，NGT）수시자진행인지、기억평고급사어（문자、수자）공작기억급객체（면공）공작기억임무하적공능성자공진검사，분석뇌격활도。결과①I GT환자적인지여N GT조상비，차이무통계학의의（t＝0.459，P＝0.635）。②여NGT조상비，IGT조재문자공작기억중우측섭협、섭상회（brodmann area 22，BA22구）등뇌구격활감약（t＝55.81，P＝0.009）；수자공작기억중，우측두상핵、각핵등뇌구격활감약（t＝216.84，P＝0.009）；객체공작기억중：우측미상핵체격활감약（t＝5.09，P＝0.008）。결론 IGT환자사어급객체공작기억경전격활뇌구가능존재손해。
Objective To investigate the working memory in the patients with impaired glucose tolerance (IGT)by functional magnetic resonance imaging (fMRI).Methods Verbal and objective working memory tasks were performed in 1 3 patients with IGT and 1 9 persons with normal glucose tolerance (NGT)while performing fMRI.The cognitive function,memory function and the activation map were analyzed.Results ① There was no significant difference in cognition function between the NGT and IGT group (t=0.459,P=0.635).②Compared with NGT group,there was less activation of right temporal and superior temporal gyrus (BA22)area in IGT group during word working memory;less activation of right putamen,lenticular body in IGT group during number working memory;less activation of right caudate body in IGT group during object working memory (P<0.01 ).Conclusion IGT group may have lesions in the classic activation areas during verbal working memory and object memory.