CAJ | 학술논문

目的对轻度肝功能异常进行开胸手术的患者，研究使用右美托咪定复合丙泊酚、瑞芬太尼进行麻醉的效果及适宜剂量。方法选取150例我院2012年4月~2014年4月收治的轻度肝功能异常患者，所有患者均需要行开胸术。将以上患者随机分为观察组A、观察组B、对照组各50例。观察组A、观察组B患者在麻醉诱导前15min静脉滴注右美托咪定负荷剂量0.8μg/kg，并分别在麻醉诱导行气管插管后开始静脉泵注右美托咪定0.2μg/(kg·h)、0.5μg/(kg·h)维持直到手术结束前0.5h；对照组患者给予等量的生理盐水静脉注射。结果观察组B患者的HR情况和不良反应发生率与观察组A患者相比，明显较好，P<0.05；观察组A患者的HR情况和不良反应发生率与对照组患者，明显较好，P<0.05。结论可见丙泊酚-瑞芬太尼复合0.5μg/(kg·h)右美托咪定是最佳维持剂量。
목적대경도간공능이상진행개흉수술적환자，연구사용우미탁미정복합병박분、서분태니진행마취적효과급괄의제량。방법선취150례아원2012년4월~2014년4월수치적경도간공능이상환자，소유환자균수요행개흉술。장이상환자수궤분위관찰조A、관찰조B、대조조각50례。관찰조A、관찰조B환자재마취유도전15min정맥적주우미탁미정부하제량0.8μg/kg，병분별재마취유도행기관삽관후개시정맥빙주우미탁미정0.2μg/(kg·h)、0.5μg/(kg·h)유지직도수술결속전0.5h；대조조환자급여등량적생리염수정맥주사。결과관찰조B환자적HR정황화불량반응발생솔여관찰조A환자상비，명현교호，P<0.05；관찰조A환자적HR정황화불량반응발생솔여대조조환자，명현교호，P<0.05。결론가견병박분-서분태니복합0.5μg/(kg·h)우미탁미정시최가유지제량。
Objective For patients with mild liver function abnormalities were thoracotomy,Studies using dexmedetomidine given propofol,Remifentanil anesthesia ef icacy and appropriate dose.Methods Select the 150 cases in our hospital during 2012.4-2014.4 patients with mild hepatic dysfunction,al the patients must need a thoracotomy.The more patients were randomly divided into two groups A, observation group B,control group of 50 cases.Observation group A,group B patients was observed before induction of anesthesia 15min dexmedetomidine infusion given a loading dose of 0.8μg/kg,And respectively Intravenous infusion of dexmedetomidine given 0.2μgokg-1oh-after induction of anesthesia endotracheal intubation,0.5μgokg-1oh until half an hour before the end of surgery;In the control group were treated with normal saline intravenously.Results HR situation observed in patients in group B and the incidence of adverse reactions Compared with the observation group A patients,significantly bet er, <0.05.Conclusion Propofol-remifentanil 0.5μgokg-1oh-1 dexmedetomidine is the best maintenance dose given,worthy of clinical application.