河北医药
河北醫藥
하북의약
HEBEI MEDICAL JOURNAL
2015年
4期
491-494
,共4页
幽门螺杆菌感染%眼底动脉硬化%冠状动脉粥样硬化性心脏病%13 C呼气试验
幽門螺桿菌感染%眼底動脈硬化%冠狀動脈粥樣硬化性心髒病%13 C呼氣試驗
유문라간균감염%안저동맥경화%관상동맥죽양경화성심장병%13 C호기시험
helicobacter pylori%ocular fundus arteriosclerosis%coronary heart disease%13C-breath test
目的：探讨幽门螺杆菌（helicobacter pylori，H．pylori）感染和眼底动脉硬化（OFA）与冠状动脉粥样硬化性心脏病（CAD）的相关性。方法根据冠状动脉造影（CAG）的结果，将305例研究对象分为非CAD组和CAD组。所有病例均行13 C-呼气试验、血浆H．pylori抗体（ H．pylori IgG ）测定及眼底动脉检查；同时收集病史、血常规、血生化、尿微量白蛋白（ UMA）、高敏C反应蛋白（ hs-CRP）、糖化血红蛋白水平等指标，评价H．pylori感染、OFA与CAD的相关性。结果 CAD组13 C呼气试验H．pylori 感染、OFA阳性率明显高于非CAD组（ P ＜0 K．05）； CAD组13 C呼气试验H．pylori感染δ值明显高于非CAD组（ P ＜0．05）。综合H．pylori感染、眼底动脉硬化程度及其他危险因素后，发现H．pylori≥4‰、OFA≥Ⅱ级、糖尿病、年龄≥65岁与CAD具有较强的相关性（ P ＜0．05）。结论 H．pylori感染、OFA与CAD具有一定的相关性。
目的：探討幽門螺桿菌（helicobacter pylori，H．pylori）感染和眼底動脈硬化（OFA）與冠狀動脈粥樣硬化性心髒病（CAD）的相關性。方法根據冠狀動脈造影（CAG）的結果，將305例研究對象分為非CAD組和CAD組。所有病例均行13 C-呼氣試驗、血漿H．pylori抗體（ H．pylori IgG ）測定及眼底動脈檢查；同時收集病史、血常規、血生化、尿微量白蛋白（ UMA）、高敏C反應蛋白（ hs-CRP）、糖化血紅蛋白水平等指標，評價H．pylori感染、OFA與CAD的相關性。結果 CAD組13 C呼氣試驗H．pylori 感染、OFA暘性率明顯高于非CAD組（ P ＜0 K．05）； CAD組13 C呼氣試驗H．pylori感染δ值明顯高于非CAD組（ P ＜0．05）。綜閤H．pylori感染、眼底動脈硬化程度及其他危險因素後，髮現H．pylori≥4‰、OFA≥Ⅱ級、糖尿病、年齡≥65歲與CAD具有較彊的相關性（ P ＜0．05）。結論 H．pylori感染、OFA與CAD具有一定的相關性。
목적：탐토유문라간균（helicobacter pylori，H．pylori）감염화안저동맥경화（OFA）여관상동맥죽양경화성심장병（CAD）적상관성。방법근거관상동맥조영（CAG）적결과，장305례연구대상분위비CAD조화CAD조。소유병례균행13 C-호기시험、혈장H．pylori항체（ H．pylori IgG ）측정급안저동맥검사；동시수집병사、혈상규、혈생화、뇨미량백단백（ UMA）、고민C반응단백（ hs-CRP）、당화혈홍단백수평등지표，평개H．pylori감염、OFA여CAD적상관성。결과 CAD조13 C호기시험H．pylori 감염、OFA양성솔명현고우비CAD조（ P ＜0 K．05）； CAD조13 C호기시험H．pylori감염δ치명현고우비CAD조（ P ＜0．05）。종합H．pylori감염、안저동맥경화정도급기타위험인소후，발현H．pylori≥4‰、OFA≥Ⅱ급、당뇨병、년령≥65세여CAD구유교강적상관성（ P ＜0．05）。결론 H．pylori감염、OFA여CAD구유일정적상관성。
Objective To investigate the correlation between Helicobacter pylori ( Hp ) infection and coronary atherosclerotic heart disease ( CAD) as well as ocular fundus arteriosclerosis ( OFA) .Methods According to the results of the coronary angiography(CAG),the 305 patients were divided into non-CAD group and CAD group,all the patients underwent 13C-breath test,Hp IgG antibody determination and OFA,at the same time,the patien’ s case history was colleted, microalbuminuria ( UMA) , high sensitivity C-reactive protein ( Hs-CRP ) were detected and blood routine test , biochemical parameter examination ,glycosylated hemoglobin test were performed to evaluate the correlation between Hp infection and OFA as well as CAD.Results According to the results of 13 C-breath test,the positive rates of Hp infection in CAD group were significantly higher than those in non-CAD group( P <0.05),at the same time,theδvalue of Hp infection in CAD group was significantly higher than that in non-CAD group( P <0.05).There was a close correlation between CAD and Hp≥4‰,OFA≥Ⅱgrade,diabetes mellitus,age≥65 years( P <0.05).Conclusion Hp infection is correlated with OFA and CAD at some extent.
