CAJ | 학술논문

目的：研究间充质干细胞( MSC )在治疗肝移植术后急性排斥反应的护理方法及效果。方法回顾性分析2006—2012年行同种异体原位全肝移植(经典非转流)手术后出现急性排斥反应的10例患者,对输注MSC的过程进行规范护理和临床观察的分析。结果10例患者治疗前后SAS评分分别为(52.6±9.4)分和(40.3±8.2)分,治疗前后差异有统计学意义(t=3.118,P<0.01)；患者术前每晚平均睡眠时间为(6.3±0.7)h,术后为(7.6±0.9)h,差异有统计学意义(t=-3.606,P<0.01)；治疗前后10例患者血压有所改善,差异有统计学意义(P<0.05)。10例患者自觉症状在输注完MSC后较入院时均有不同程度的改善,与治疗前比较差异有统计学意义(P<0.05)。10例患者均无严重不良反应出现。结论重视和规范肝移植术后输注MSC的护理流程有利于改善患者的心理状态,减少不良反应,提高其治疗效果。
목적：연구간충질간세포( MSC )재치료간이식술후급성배척반응적호리방법급효과。방법회고성분석2006—2012년행동충이체원위전간이식(경전비전류)수술후출현급성배척반응적10례환자,대수주MSC적과정진행규범호리화림상관찰적분석。결과10례환자치료전후SAS평분분별위(52.6±9.4)분화(40.3±8.2)분,치료전후차이유통계학의의(t=3.118,P<0.01)；환자술전매만평균수면시간위(6.3±0.7)h,술후위(7.6±0.9)h,차이유통계학의의(t=-3.606,P<0.01)；치료전후10례환자혈압유소개선,차이유통계학의의(P<0.05)。10례환자자각증상재수주완MSC후교입원시균유불동정도적개선,여치료전비교차이유통계학의의(P<0.05)。10례환자균무엄중불량반응출현。결론중시화규범간이식술후수주MSC적호리류정유리우개선환자적심리상태,감소불량반응,제고기치료효과。
Objective To investigate clinical nursing for acute liver allograft rejection with mesenchymal stem cells ( MSC ) therapy. Methods A total of 10 patients, who underwent the allogenic orthotopic liver transplantation in our center and suffered acute rejection, were enrolled during 2006 to 2012 and investigated by regression analysis. We regulated nursing procedure and observed clinical reaction during the procedure of MSC transfusion. Results The self-rating anxiety scale ( SAS) scores for the patients in pre- and post-MSC transfusion period were (52.6 ±9.4) and (40.3 ±8.2), respectively (t=3.118,P<0.01). The sleep time were prolonged from pre-MSC transfusion ( 6. 3 ± 0. 7 ) hrs averagely to ( 7. 6 ± 0. 9 ) hrs ( t =-3.606,P < 0. 01). The blood pressure also improved after transfusion (P < 0. 05). In addition, the subjective symptoms were improved different degrees for all patients (P<0. 05), and no obvious side effects was found. Conclusions It benefits patients′ psychological state, side effects and treatment effect if attention and specification of nursing process were paid for the patients after liver transplantation with mesenchymal stem cell transfusion.