CAJ | 학술논문

合成了小粒径纳米金作为卟啉保护剂,以纳米金-卟啉化合物和pH指示剂共同构建6×6传感阵列,将其用于可视化检测12种肺癌患者呼出气体中的有机小分子( OSMs),设置了3个浓度梯度且每个样品重复5次。实验结果显示,纳米金的引入可显著提高阵列的稳定性和灵敏度；聚类分析结果表明,5次平行实验的结果优先聚为一簇,结构相似的目标物随后聚在一起；差谱图显示该方法对不同种类、不同浓度的OSMs具有良好的定性及半定量分析能力。该方法可快速识别OSMs且具有肺癌筛查的潜在应用前景。
합성료소립경납미금작위계람보호제,이납미금-계람화합물화pH지시제공동구건6×6전감진렬,장기용우가시화검측12충폐암환자호출기체중적유궤소분자( OSMs),설치료3개농도제도차매개양품중복5차。실험결과현시,납미금적인입가현저제고진렬적은정성화령민도；취류분석결과표명,5차평행실험적결과우선취위일족,결구상사적목표물수후취재일기；차보도현시해방법대불동충류、불동농도적OSMs구유량호적정성급반정량분석능력。해방법가쾌속식별OSMs차구유폐암사사적잠재응용전경。
The smaller gold nanoparticles( AuNPs) were synthesized and used as a protectant for metal tetra-phenylporphyrins( MTPP) , and a 6í6 sensor array was constructed together by AuNPs-MTPP compounds and pH indicators to detect 12 organic small molecules( OSMs) in exhaled breath of lung cancer patients with three concentration gradients, and each test was repeated five times. The protective effect showed that the stability and sensitivity of the array were significantly enhanced due to the introduction of AuNPs; hierarchical cluster analysis( HCA) indicated that the results of five parallel experiments gathered into a cluster firstly, and target objects with similar structure were gotten together subsequently;digital color difference maps of OSMs with dif-ferent kinds and concentrations visually displayed that the proposed method had good capability for qualitative and semi-quantitative analysis. The method can be used for fast identification of OSMs and has potential appli-cation prospect in lung cancer screening.