CAJ | 학술논문

整合素是一类由α、β两个亚基组成的异源二聚体，是一种细胞黏附分子；其配体是细胞外基质成分，参与细胞黏附、信号转导、血管生成等众多生理、病理过程，具有广泛的生物学功能。血管生成是指在微血管床上芽生出新的以毛细血管为主的血管系统，此过程离不开整合素。整合素与众多促血管生成的细胞因子交互作用，通过参与内皮细胞的激活、迁移、增殖和抑制内皮细胞凋亡等过程，从而在血管生成过程中起着重要的作用。该文就整合素与血管生成的关系研究进展予以综述。
정합소시일류유α、β량개아기조성적이원이취체，시일충세포점부분자；기배체시세포외기질성분，삼여세포점부、신호전도、혈관생성등음다생리、병리과정，구유엄범적생물학공능。혈관생성시지재미혈관상상아생출신적이모세혈관위주적혈관계통，차과정리불개정합소。정합소여음다촉혈관생성적세포인자교호작용，통과삼여내피세포적격활、천이、증식화억제내피세포조망등과정，종이재혈관생성과정중기착중요적작용。해문취정합소여혈관생성적관계연구진전여이종술。
As a kind of cell adhesion molecules,integrin is a heterodimer,which composed of αand βsubunits.With extracellular matrix components as its ligand,integrin involves in cell adhesion, signal trans-duction,angiogenesis,and other physiological and pathological processes,boasting a wide range of biological functions.Angiogenesis is the process of sprouting new capillary-based vascular system in the microvascular bed.It′s inseparable from integrin,which interacts with many cytokines stimulating vascularization and plays an important role in angiogenesis through participating in endothelial cell′s activation、migration、prolifera-tion,inhibiting apoptosis of endothelial cell and so on.