CAJ | 학술논문

EB病毒（EBV）在感染宿主的过程中需要克服宿主免疫系统的防御，因此衍生了一系列干扰人体免疫的策略。 EBV感染后会长期潜伏在宿主B细胞中，并对宿主MHC分子的表达进行干扰，影响宿主的抗病毒免疫。 EBV表达的BCRF1蛋白可刺激Th2细胞的产生，BARF1蛋白可诱发α型干扰素等细胞因子的分泌，多种病毒蛋白均可干扰细胞因子网络。同时 EBV 编码的 BHRF1等蛋白可发挥抗凋亡作用。该文就EBV免疫逃避的最新研究进展进行了归纳总结，以期为EBV防控、新型疫苗设计等提供参考。
EB병독（EBV）재감염숙주적과정중수요극복숙주면역계통적방어，인차연생료일계렬간우인체면역적책략。 EBV감염후회장기잠복재숙주B세포중，병대숙주MHC분자적표체진행간우，영향숙주적항병독면역。 EBV표체적BCRF1단백가자격Th2세포적산생，BARF1단백가유발α형간우소등세포인자적분비，다충병독단백균가간우세포인자망락。동시 EBV 편마적 BHRF1등단백가발휘항조망작용。해문취EBV면역도피적최신연구진전진행료귀납총결，이기위EBV방공、신형역묘설계등제공삼고。
In order to resist the host immune system in the infection process ,EB virus ( EBV) produced a series of interference of human immune system.EBV can latent in the B cells of host for a long-term after infection and interference the expression of host MHC to affect the host immune system .EBV BCRF1 protein can induce the creation of Th2 cells,BARF1 protein can induce secretion of IFN-α.Many viral proteins could interfere in the cytokine network.The BHRF1 protein encoded by EBV may play an anti apoptotic role in host body.This paper describes many mechanisms of EBV to evade from the host immune .In this paper, latest re-search progress in immune evasion of EBV is summarized to provide a reference for EBV prevention and con-trol as well as the design of new vaccines.